PG Versus TG for Advanced PGC

NCT ID: NCT06614439

Last Updated: 2025-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

96 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-04

Study Completion Date

2025-09-01

Brief Summary

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We conducted a retrospective study on patients with pathological stage II-III PGC who underwent PG or TG from 2013 to 2023. Propensity score-matching was applied to adjust for tumor size and stage between the PG and TG groups at a 1:1 ratio. We evaluated the procedural safety, oncological, and functional outcomes.

Detailed Description

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Conditions

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Gastric Adenocarcinoma Gastrectomy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Proximal gastrectomy

Group Type EXPERIMENTAL

proximal gastrectomy

Intervention Type PROCEDURE

proximal gastrectomy

Total gastrectomy

Group Type ACTIVE_COMPARATOR

total gastrectomy

Intervention Type PROCEDURE

total gastrectomy

Interventions

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proximal gastrectomy

proximal gastrectomy

Intervention Type PROCEDURE

total gastrectomy

total gastrectomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Proximal gastric adenocarcinoma after total or proximal gastrectomy.

Exclusion Criteria

* Non-curative resections
* Non-adenocarcinoma histology
* Distally located tumors or middle/proximally located tumors for which distal margin could not be secured by PG
* Remnant gastric cancer
* Clinically T1N0 tumors smaller than 3 cm for which PG was clearly indicated
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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National Taiwan University Hospital Hsin-Chu Branch

Hsin-Chu County, , Taiwan

Site Status

Countries

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Taiwan

References

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Lee S, Chae YS, Yun WG, Kim JC, Park JK, Kim MG, Kim J, Cho YS, Kong SH, Park DJ, Lee HJ, Yang HK. Long-Term Outcome of Proximal Gastrectomy for Upper-Third Advanced Gastric and Siewert Type II Esophagogastric Junction Cancer Compared With Total Gastrectomy: A Propensity Score-Matched Analysis. Ann Surg Oncol. 2024 May;31(5):3024-3030. doi: 10.1245/s10434-024-15048-8. Epub 2024 Feb 19.

Reference Type BACKGROUND
PMID: 38372863 (View on PubMed)

Peng R, Yue C, Wei W, Zhou B, Wen X, Gu RM, Ming XZ, Li G, Chen HQ, Xu ZK. Proximal gastrectomy may be a reasonable choice for patients with selected proximal advanced gastric cancer: A propensity score-matched analysis. Asian J Surg. 2022 Oct;45(10):1823-1831. doi: 10.1016/j.asjsur.2021.09.029. Epub 2021 Oct 9.

Reference Type BACKGROUND
PMID: 34642056 (View on PubMed)

Rosa F, Quero G, Fiorillo C, Bissolati M, Cipollari C, Rausei S, Chiari D, Ruspi L, de Manzoni G, Costamagna G, Doglietto GB, Alfieri S. Total vs proximal gastrectomy for adenocarcinoma of the upper third of the stomach: a propensity-score-matched analysis of a multicenter western experience (On behalf of the Italian Research Group for Gastric Cancer-GIRCG). Gastric Cancer. 2018 Sep;21(5):845-852. doi: 10.1007/s10120-018-0804-3. Epub 2018 Feb 8.

Reference Type BACKGROUND
PMID: 29423892 (View on PubMed)

Sugoor P, Shah S, Dusane R, Desouza A, Goel M, Shrikhande SV. Proximal gastrectomy versus total gastrectomy for proximal third gastric cancer: total gastrectomy is not always necessary. Langenbecks Arch Surg. 2016 Aug;401(5):687-97. doi: 10.1007/s00423-016-1422-3. Epub 2016 May 4.

Reference Type BACKGROUND
PMID: 27143021 (View on PubMed)

Lee S, Son WJ, Roh YH, Song JH, Park SH, Cho M, Kim YM, Hyung WJ, Kim HI. Indication of Proximal Gastrectomy for Advanced Proximal Gastric Cancer Based on Lymph Node Metastasis at the Distal Part of the Stomach. Ann Surg Open. 2021 Nov 24;2(4):e107. doi: 10.1097/AS9.0000000000000107. eCollection 2021 Dec.

Reference Type BACKGROUND
PMID: 37637877 (View on PubMed)

Other Identifiers

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202408135RIND

Identifier Type: -

Identifier Source: org_study_id

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