Impact of Endometrial Compaction on Clinical Pregnancy Rate in Frozen Embryo Transfers

NCT ID: NCT06583265

Last Updated: 2024-09-04

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-01-01
• Study Completion Date: 2024-09-30

Brief Summary

To find out if the percentage of endometrial compaction is correlated to clinical pregnancy rate in down regulated frozen embryo transfer cycle. Endometrial compaction is the change in endometrial thickness between the end of the estrogen only phase and the day of embryo transfer. In concept, the compaction of the endometrium after progesterone initiation indicates that the endometrium is responsive to progesterone and could therefore be used as a proxy for endometrial receptivity predictability of FET cycle outcome

Conditions

IVF

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Infertility patients planning for FET

Observational

Intervention Type: DRUG

To observe if endometrial compaction ≥ 5% in down regulated FET cycles increases clinical pregnancy rate.

Interventions

Observational

To observe if endometrial compaction ≥ 5% in down regulated FET cycles increases clinical pregnancy rate.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Women undergoing down regulated cycles frozen embryo transfer.
• Women at age group 20-35 years old.
• Day 5 embryos will be transferred.

Exclusion Criteria

• Chromosomal abnormality in either partner (As this could lead to cycle cancellation).
• Uterine malformation or any intrauterine condition affecting the pregnancy outcomes of FET, such as endometrial polyps, uterine cavity adhesion, history of endometrial tuberculosis, hydrosalpinx with a reflux into uterine cavity (As the might not be candidates for IVF cycle till correction).
• Recurrent implantation failure, defined as 2 or more previous failed trials (Other confounding factors might of present which could affect the results).
• Cycles of patients with persistent endometrial thickness <7mm during treatment protocol (Due to cycled cancelation).

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Ain Shams University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Ain Shams University

Cairo, , Egypt

Site Status: RECRUITING

Countries

Egypt

Facility Contacts

Passant Eid, MBBCH

Role: primary

emp14094@med.asu.edu.eg

01119405010

Other Identifiers

Endometrial Compaction

Identifier Type: -

Identifier Source: org_study_id