Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
90 participants
INTERVENTIONAL
2005-12-31
Brief Summary
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Detailed Description
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Purpose
1. To determine whether performing curettage the month prior to embryo transfer (ET) increases the chance of embryo implantation.
2. To study molecular attributes of the endometrium taken at curettage and to compare them to those cycles resulting in pregnancy and those which do not result in pregnancy.
Samples will be grown as primary culture in the research laboratory and possible molecular markers and attachment assays for endometrial receptivity will be studied.
Patient selection: Patients undergoing IVF or IVF-ICSI at Ha'Emek medical center/ IVF unit. Woman over 35 years of age will be excluded since implantation failure is more likely to be due to genetic, chromosomal or cytoplasmic aberrations in their oocytes.
Proposed protocol:
1. Informed consent obtained from prospective candidates.
2. Participants randomly divided to three groups
1. Control group
2. Hysteroscopy and curettage performed on days 15-17 of menstrual cycle
3. Hysteroscopy and curettage performed on days 19-22 of menstrual cycle
3. After the following menses an IVF, IVF-ICSI, or frozen embryo cycle is performed according to the unit's standard protocols.
4. The primary end point of the study will be the implantation rate after ET and the expression of possible molecular markers for endometrial receptivity in the pregnant patients.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Interventions
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Hysteroscopy and Curettage
Eligibility Criteria
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Inclusion Criteria
* In-vitro fertilization candidate
* Normal blood coagulation
Exclusion Criteria
* Abnormal maternal karyotype
* Thrombocytopenia under 140,000
* Any contraindication to hysteroscopy or in-vitro fertilization
18 Years
35 Years
FEMALE
Yes
Sponsors
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Technion, Israel Institute of Technology
OTHER
HaEmek Medical Center, Israel
OTHER
Principal Investigators
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Joel Geslevich, MD
Role: PRINCIPAL_INVESTIGATOR
haemek medical center
Eliezer Shalev
Role: STUDY_CHAIR
HaEmek Medicak Center and Technion, Israel Institute of Technology
Shlomit Goldman
Role: STUDY_DIRECTOR
haemek medical center
Locations
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Department of Obstetrics and gynecology, HaEmek Medical Center
Afula, , Israel
Countries
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Central Contacts
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References
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La Sala GB, Montanari R, Dessanti L, Cigarini C, Sartori F. The role of diagnostic hysteroscopy and endometrial biopsy in assisted reproductive technologies. Fertil Steril. 1998 Aug;70(2):378-80. doi: 10.1016/s0015-0282(98)00147-2.
Barash A, Dekel N, Fieldust S, Segal I, Schechtman E, Granot I. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril. 2003 Jun;79(6):1317-22. doi: 10.1016/s0015-0282(03)00345-5.
Other Identifiers
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Ministry of Heath:920050038
Identifier Type: -
Identifier Source: secondary_id
Genetics committee: 2005-061
Identifier Type: -
Identifier Source: secondary_id
3280105
Identifier Type: -
Identifier Source: org_study_id