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Estradiol, Progesterone and Endometrial Thickness in Frozen Euploid Embryo Transfer

NCT ID: NCT03395665

Last Updated: 2018-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

299 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-31

Study Completion Date

2018-01-31

Brief Summary

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The development and improvement in Preimplantation genetic diagnosis/screening (PGS) in association with the efficacy and security of vitrification and trophectoderm biopsy, more efficient stimulation schemes and laboratory improvements in culture and embryo selection have contributed to high success of the assisted reproductive technologies(ART). Transferring an euploid embryo avoids one of the main reasons of miscarriage and implantation failure ( Rubio et al, 22016) and overcomes one of the most important confounding factors. Usually, the transfer of euploid embryos is performed under standard hormone replacement therapy (HRT) and are referred to as FET-PGS cycles( Frozen embryo transfer). The study of FET-PGS cycles with the transfer of a single euploid blastocyst is the best model for evaluation of the impact of the endometrial preparation . Among factors influencing FET outcomes, patient's age, endometrial preparation, endometrium thickness, endometrial pattern, number and quality of embryos transferred , difficulty at ET, recently P4 have received more attention .

The importance of Progesterone (P4) in embryo implantation has been widely studied. P4 plays an important role in endometrial gland formation, embryonic implantation and pregnancy maintenance, both in natural and artificial cycles.

Detailed Description

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Conditions

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Infertility Preimplantation Genetic Diagnosis/Screening Miscarriage

Study Design

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Observational Model Type

CASE_CROSSOVER

Study Time Perspective

RETROSPECTIVE

Interventions

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Estradiol level

Estradiol level measured at previous day of embryo transfer procedure

Intervention Type OTHER

Progesterone level

Progesterone level measured at previous day of embryo transfer procedure

Intervention Type OTHER

Endometrial thickness

Endometrial thickness measured at previous day of embryo transfer procedure

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Frozen embryo transfer (FET) of at least one single euploid embryo.
* Estradiol \> 75pg/ml.
* Progesterone \> 4 ng/ml.
* Endometrial thickness between 6 mm and 18 mm.

Exclusion Criteria

* Patients with FET of no diagnostic or mosaic embryos, or known uterine abnormality were excluded.
* Natura cycle protocol.
Minimum Eligible Age

18 Years

Maximum Eligible Age

43 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Fundacion Dexeus

OTHER

Sponsor Role lead

Responsible Party

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Buenaventura Coroleu

Head of Reproductive Medicine Service

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Obstetrics, Gynaecology and Reproduction Instituto Universitario Dexeus

Barcelona, , Spain

Site Status

Countries

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Spain

Related Links

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http://www.dexeus.com

Related Info

Other Identifiers

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SMD-2018-01

Identifier Type: -

Identifier Source: org_study_id