Immunogenicity and Thrombotic Potential of Circulating Protamine-heparin Complexes in Cardiac Surgery Patients
NCT ID: NCT06565364
Last Updated: 2024-08-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
160 participants
OBSERVATIONAL
2019-01-07
2023-03-31
Brief Summary
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The second aim was to identify triggers of immunization.
The third aim of this study was to evaluate a potential clinical impact of protamine/heparin antibodies and their platelet-activating properties leading to thromboembolism and other adverse outcomes.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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"ZYMUTEST™ HIA" immunoglobulin g ELISA (enzyme-linked immunosorbent assay )
The enzyme-linked immunosorbent assay is an in vitro test done in the laboratory to detect specific antibodies against heparin/platelet factor-4 and protamine/heparin complexes.
Eligibility Criteria
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Inclusion Criteria
* cardiac surgery on cardiopulmonary bypass
Exclusion Criteria
* age \< 18 years
* no written consent
18 Years
99 Years
ALL
No
Sponsors
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Medical University of Vienna
OTHER
Responsible Party
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Caroline Holaubek, MD
Medical Doctor, Research Fellow
Principal Investigators
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Barbara Steinlechner, MD
Role: PRINCIPAL_INVESTIGATOR
Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna
Locations
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Medical University of Vienna
Vienna, , Austria
Countries
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Other Identifiers
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EK Nr: 1895/2014
Identifier Type: -
Identifier Source: org_study_id
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