Trans Canal Tympanoplasty With Local Anesthesia Using Fat Graft and "TachoSil"

NCT ID: NCT06542367

Last Updated: 2024-08-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-01

Study Completion Date

2026-09-01

Brief Summary

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Eligible participants with chronic tympanic membrane perforation (\>6 month) will be given a detailed description and offered to participate in the study.

the study investigates the efficacy of trans canal tympanoplasty with local anesthesia using fat pad and "Tachosil". Participants will be followed for 1 year after the procedure with otological examination and successive hearing evaluations.

Detailed Description

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Conditions

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Tympanic Membrane Perforation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Transcanal tympanoplasty under local anasthesia with fat graft and "Tachosil"

eligibale participatns with chronic tympanic membrane perforation will be offered to participate.

Under local anesthesia, subcutaneous fat from the neck will be harvested. After that trimming of the perforation edges, planting the fat graft medial to the tympanic membrane and placement of the "Tachosil" on top of the fat graft.

gelfoam is placed lateral to the tympanic membrane fo fill the ear canal. follow-up will be held at 2, 4-6 and 12 month following the procedure, with audiometric and otological evaluation

Group Type EXPERIMENTAL

Tympanoplasty performed under local anesthesia using fat graft and "Tachosil".

Intervention Type PROCEDURE

Under local anesthesia, subcutaneous fat from the neck will be harvested. After that trimming of the perforation edges, planting the fat graft medial to the tympanic membrane and placement of the "Tachosil" on top of the fat graft.

gelfoam is placed lateral to the tympanic membrane to fill the ear canal. follow-up will be held at 2, 4-6 and 12 months following the procedure, with audiometric and otological evaluation

Interventions

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Tympanoplasty performed under local anesthesia using fat graft and "Tachosil".

Under local anesthesia, subcutaneous fat from the neck will be harvested. After that trimming of the perforation edges, planting the fat graft medial to the tympanic membrane and placement of the "Tachosil" on top of the fat graft.

gelfoam is placed lateral to the tympanic membrane to fill the ear canal. follow-up will be held at 2, 4-6 and 12 months following the procedure, with audiometric and otological evaluation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Chronic tympanic membrane perforation (\>6 months).
* Central tympanic membrane perforation.
* Air bone gar of 35 dB or lower at the operated ear.
* No active otorrhea in the operated ear in the preceding 3 month prior to the procedure.
* No evidence of a retraction pocket and no suspicion for a cholesteatoma.

Exclusion Criteria

* Known ossicular chain dysfunction
* The tympanic membrane perforation edges are not accessible/visualized transcanal
* Pregnancy
* Allergy to lidocaine
Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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HaEmek Medical Center, Israel

OTHER

Sponsor Role lead

Responsible Party

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Yoni Evgeni Gutkovich

Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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yoni Evgeni Gutkovich, M.D/Ph.D

Role: CONTACT

+972-46495563

Lev Shlizerman, M.D

Role: CONTACT

+972-46495563

Other Identifiers

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0047-24-EMC

Identifier Type: -

Identifier Source: org_study_id

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