B-catenin in Cutaneous Squamous Cell Carcinoma and Its Mimickers

NCT ID: NCT06536946

Last Updated: 2024-08-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-01

Study Completion Date

2025-09-30

Brief Summary

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Examine the role of B-catenin in differentiation of cutaneous squamous cell carcinoma from other lesions that may be similar to it

Detailed Description

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Skin cancer is one of the most common form of cancer worldwide. Cutaneous squamous cell carcinoma is one of most common skin tumers that caused by many factors as ultra violet ,ionizing radiation and others . It was an advanced spectrum ranging from actinic keratosis to invasive and metastatic squmous cell carcinoma. Correct identification of cutaneous squamous cell carcinoma is a challenge as it has both clinically and histopathologically mimickers.

So the aim of this study is to identify the expression of B-catenin in cutaneous Squamous cell carcinoma and its mimickers.

Conditions

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Cutaneous Squamous Cell Carcinoma

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Participants

50 formalin fixed parrafin embedded tissue blocks of cutaneous squamous cell carcinoma and its mimickers , from each block 2 tissue section; one tissue section stained by Hematoxilin and Eoisin and other tissue section will be stained immunohistochemically by anti human B-catenin

Immunohistochemical staining

Intervention Type BIOLOGICAL

Staining of cutanous squamous cell carcinoma and its mimickers by monoclonal antibodies against human B-catenin by immunohistochemical procedures

Interventions

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Immunohistochemical staining

Staining of cutanous squamous cell carcinoma and its mimickers by monoclonal antibodies against human B-catenin by immunohistochemical procedures

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* tissue blocks with sufficient materials Cases with sufficient data

Exclusion Criteria

* tissue blocks with insufficient and necrotic materials. Casas with insufficient data
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Nermin Sarwat Habib

Teaching assistant of pathology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Sohag University hospital

Sohag, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Nermeen S Habeeb, Doctor

Role: CONTACT

01200496394

Facility Contacts

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Magdy M Amen, Professor

Role: primary

Nermeen S Habeeb, Doctor

Role: backup

01200496394

Other Identifiers

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Soh-Med-25-05-07MS

Identifier Type: -

Identifier Source: org_study_id

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