ERAP1,2 in Recalcitrant Warts

NCT ID: NCT06833164

Last Updated: 2025-02-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-10-01

Study Completion Date

2024-03-20

Brief Summary

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The exact mechanisms underlying the contribution of cellular immunity in the eradication of human papillomavirus (HPV) infections remain obscure. Individuals who have treatment-resistant warts frequently have immune deficiencies. Amino-peptidases (ERAP1, ERAP2) of endoplasmic reticulum are essential for production of antigenic epitopes that attach to the Major Histocompatibility Complex (MHC) class I and activate T-lymphocytes or natural killer (NK) cells. Aim: To assess ERAP1 and ERAP2 serum concentrations in patients with resistant warts.

Detailed Description

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Conditions

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Warts

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Interventions

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endoplasmic reticulum Aminopeptidase 1 and 2

endoplasmic reticulum aminopeptidase1 and 2 serum levels determination via ELISA

Intervention Type DIAGNOSTIC_TEST

endoplasmic reticulum aminopeptidase 1 and 2 serum levels determination via ELISA

endoplasmic reticulum aminopeptidase 1 and 2 serum levels determination via ELISA

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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SEUM ERAP1 MEASUREMENT USING ELISA SERUM ERAP2MEASUREMENT USING ELISA

Eligibility Criteria

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Inclusion Criteria

• Patients who had a history of incomplete clearance or recurrence following two or more electrocautery sessions and four or more cryocautery treatments and intralesional bleomycin.

Exclusion Criteria

* Patients with genital warts
* Patients on systemic steroids or other immunosuppressive treatments
* Immunocompromised individuals
* Patients suffering from chronic systemic diseases
* Pregnant women
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Benha University

OTHER

Sponsor Role lead

Responsible Party

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karem Taha ibrahim khalil

assistant professor of dermatology, venereology and andrology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ihab Y. Abdallah, MD

Role: STUDY_CHAIR

Professor of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University

Nehad A.Fouad, MD

Role: STUDY_DIRECTOR

Professor of Microbiology and Immunology, Faculty of Medicine, Benha University

Ola S Ebrahim, MBBCh

Role: PRINCIPAL_INVESTIGATOR

Benha University

Locations

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faculty of medicine Benha University

Banhā, Qalyubia Governorate, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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Serum ERAP1 and 2 in warts

Identifier Type: -

Identifier Source: org_study_id

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