A Study of Enterorenal Syndrome Assessed by Gastrointestinal Ultrasound Combined with Renal Artery Resistance Index

NCT ID: NCT06505512

Last Updated: 2025-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

74 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-19

Study Completion Date

2025-03-31

Brief Summary

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In this study, the patients with sepsis caused by abdominal infection were divided into survival group and death group by ultrasound examination of gastrointestinal function, superior mesenteric artery blood flow, and renal artery resistance index. The cross-sectional area of gastric antrum, average time flow rate of superior mesenteric artery, colon diameter, colon peristalsis frequency, and renal artery resistance index of the two groups were compared to determine the progression of entero-renal syndrome as soon as possible. To provide reliable objective basis for clinical decision-making, in order to improve the success rate of rescue.

Detailed Description

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Adult patients admitted to EICU of our hospital who met the diagnostic criteria for sepsis were included in the study. Patients with intra-abdominal sepsis were divided into survival group and death group for case control. Exclusion criteria: open chest and abdomen injury, advanced tumor, uremia, pregnancy. The primary endpoint was survival. Extraction time: ICU (0h), ICU (6h, that is, after fluid resuscitation), ICU (24h), ICU (48h, 08:00 a.m.), ICU (72h, 08:00 a.m.), ICU (120h, 08:00 a.m.); Monitoring indicators: antral cross-section area, colon diameter, colon peristalsis frequency, renal artery resistance index, CVP, ScvO2, IL6, blood lactic acid, blood creatinine, fluid intake, bladder pressure. The primary endpoint of the study was survival rate, and statistical analysis was performed to evaluate the progression of enterorenal syndrome, provide reliable objective basis for subsequent clinical decision-making, and improve the success rate of rescue.

Conditions

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Sepsis Urinary Tract Infections

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Survival group

Patients who get better after treatment and eventually survive.

No intervention

Intervention Type DIAGNOSTIC_TEST

No intervention

Death group

Patients who die within 28 days of hospitalization.

No intervention

Intervention Type DIAGNOSTIC_TEST

No intervention

Interventions

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No intervention

No intervention

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with intra-abdominal infections
* Patients with sepsis or septic shock

Exclusion Criteria

* Patients with open chest or abdominal injury
* Patients with advanced tumor
* Patients with uremia
* Pregnant women
Minimum Eligible Age

14 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Zhangzhou Municipal Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hui Jiang, Dr.

Role: PRINCIPAL_INVESTIGATOR

the Ethnics Committee of Zhangzhou Municipal Hospital of Fujian Province

Locations

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Qingjiang Zheng

Zhangzhou, Fujian, China

Site Status RECRUITING

Countries

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China

Central Contacts

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De Kang, Dr.

Role: CONTACT

+8613960163029

Facility Contacts

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Qingjiang Zheng, M.D.

Role: primary

8613799824987

Other Identifiers

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zqj123456

Identifier Type: -

Identifier Source: org_study_id

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