Application of Ultrasound Integrated Precision Diagnosis Technology in Prevention of Kidney Disease and Its Progress
NCT ID: NCT04044404
Last Updated: 2023-11-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
208 participants
OBSERVATIONAL
2019-04-29
2021-06-30
Brief Summary
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Combined with the dynamic changes of biomarkers (inflammatory factors, cytokines secreted by immune cells, etc.) after kidney injury, the research on the prognosis of kidney disease with ultrasound elastography technology as the core would be explored, which aims to provide a scientific basis for the application of Ultrasound Integrated Precision Diagnosis Technology.
Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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A on C group
Acute on Chronic Kidney Disease patients
Ultrasound Integrated Precision Diagnosis Technology(ultrasound elastography)
Compare the ultrasound Integrated Precision Diagnosis Technology(ultrasound elastography) with the diagnostic gold standard of kidney disease---kidney biopsy
functional delayed graft function group
patients with functional delayed graft function(fDGF) after kidney transplantation
Ultrasound Integrated Precision Diagnosis Technology(ultrasound elastography)
Compare the ultrasound Integrated Precision Diagnosis Technology(ultrasound elastography) with the diagnostic gold standard of kidney disease---kidney biopsy
Normal
without functional kidney injury
Ultrasound Integrated Precision Diagnosis Technology(ultrasound elastography)
Compare the ultrasound Integrated Precision Diagnosis Technology(ultrasound elastography) with the diagnostic gold standard of kidney disease---kidney biopsy
Interventions
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Ultrasound Integrated Precision Diagnosis Technology(ultrasound elastography)
Compare the ultrasound Integrated Precision Diagnosis Technology(ultrasound elastography) with the diagnostic gold standard of kidney disease---kidney biopsy
Eligibility Criteria
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Inclusion Criteria
3.The informed consent has been signed; 4.Abnormal renal pathology or glomerular filtration rate(GFR) (15 \<GFR\<90 ml/min.1.73 m2) or proteinuria \> 1 g/24 h due to any cause.
2. for kidney transplantation
1. 18-70 years old; gender is not limited;
2. It can cooperate with breath-holding, breath-holding and breath-exhaling movements, and communicate without obstacles.
3. The informed consent has been signed;
4. Kidney transplant recipients in our hospital from May 2019 to November 2019
Exclusion Criteria
1. Can't cooperate, can't lie down for at least 10 minutes, unconsciousness, severe hypoxia, restlessness need to rescue patients.
2. Patients with pregnancy or cancer;
3. There are other serious diseases that the researchers do not think it is suitable to participate in this experiment.
4. Absolute contraindications of renal puncture, ① Obvious bleeding tendency; ②Severe hypertension (systolic pressure greater than 180 mm Hg or diastolic pressure greater than 115 mm Hg); ③Psychiatric patients or non-cooperating operators and isolated kidney (small kidney) Or relative contraindications of renal puncture: ① Active pyelonephritis, renal tuberculosis, hydronephrosis or pyonephrosis, ②renal abscess or perirenal abscess. ③Renal tumors or renal aneurysms. ④Polycystic kidney or renal cyst. ⑤Kidney position is too high (deep inhalation of the lower pole of the kidney is not below the twelve ribs) or migratory kidney. ⑥Obesity, severe ascites.
b）for kidney transplantation
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1. Can't cooperate, can't lie down for at least 10 minutes, unconsciousness, severe hypoxia, restlessness need to rescue patients.
2. Patients with pregnancy or cancer;
3. There are other serious diseases that the researchers do not think it is suitable to participate in this experiment.
4. Absolute contraindications of renal puncture, ① Obvious bleeding tendency; ②Severe hypertension (systolic pressure greater than 180 mm Hg or diastolic pressure greater than 115 mm Hg); ③Psychiatric patients or non-cooperating operators and isolated kidney (small kidney) Or relative contraindications of renal puncture: ① Active pyelonephritis, renal tuberculosis, hydronephrosis or pyonephrosis, ②renal abscess or perirenal abscess. ③Renal tumors or renal aneurysms. ④Polycystic kidney or renal cyst. ⑤Kidney position is too high (deep inhalation of the lower pole of the kidney is not below the twelve ribs) or migratory kidney. ⑥Obesity, severe ascites.
18 Years
70 Years
ALL
No
Sponsors
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China-Japan Friendship Hospital
OTHER
Duke University
OTHER
RenJi Hospital
OTHER
Responsible Party
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Locations
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Department of nephrology , Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
China-Japan Friendship Hospital
Beijing, , China
Countries
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Other Identifiers
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2019-52-K33
Identifier Type: OTHER
Identifier Source: secondary_id
RJ2018049
Identifier Type: -
Identifier Source: org_study_id