Speech Motor Learning and Retention (Aim 2)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-01

Study Completion Date

2029-05-31

Brief Summary

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The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation (TMS). Investigators will also use functional magnetic resonance imaging (fMRI) which will enable identification of circuit-level activity which predicts either learning or retention of new movements, and hence test the specific contributions of candidate sensory and motor zones. In other studies, investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute. The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning.

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Detailed Description

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The focus of this registration is Aim 2. Specific Aim 2 assesses the temporal order in which plasticity occurs in cortical motor and sensory brain areas during speech motor learning. Plasticity is assessed using measures of cortical excitability. Specifically, auditory, somatosensory and motor evoked potentials are elicited using single pulse TMS (motor), pure tone bursts (auditory), and mentalis nerve stimulation (somatosensory). Tests of cortical excitability are interleaved with trials involving speech motor adaptation. Cortical excitability is also measured using these same measures 24 hours after learning to assess retention.

The Speech Motor Learning and Retention Master Protocol is NCT06467292.

Conditions

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Speech

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Healthy right-handed adults with normal hearing will be recruited in equal number from both sexes. All participants will be fluent English speakers.

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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MEPs (M1) / altered auditory feedback / MEPs + retention tests at 24h

Evoked potentials will be recorded from brain area M1 (motor cortex) in combination with a speech motor learning procedure known as adaptation to altered auditory feedback. Retention of learning will be tested 24h later along with additional evoked potential recordings.

Group Type EXPERIMENTAL

Adaptation

Intervention Type BEHAVIORAL

Auditory adaptation in speech

Motor evoked potentials

Intervention Type DEVICE

motor evoked potentials will be obtained in each recording block

AEPs (A1) / altered auditory feedback / AEPs + retention tests at 24h

Evoked potentials will be recorded from brain area A1 (auditory cortex) in combination with a speech motor learning procedure known as adaptation to altered auditory feedback. Retention of learning will be tested 24h later along with additional evoked potential recordings.

Group Type EXPERIMENTAL

Adaptation

Intervention Type BEHAVIORAL

Auditory adaptation in speech

Auditory evoked potentials

Intervention Type DEVICE

auditory evoked potentials will be obtained in each recording block

SEPs (S1) / altered auditory feedback / SEPs + retention tests at 24h

Evoked potentials will be recorded from brain area S1 (somatosensory cortex) in combination with a speech motor learning procedure known as adaptation to altered auditory feedback. Retention of learning will be tested 24h later along with additional evoked potential recordings.

Group Type EXPERIMENTAL

Adaptation

Intervention Type BEHAVIORAL

Auditory adaptation in speech

Somatosensory evoked potentials

Intervention Type DEVICE

Somatosensry evoked potentials will be obtained in each recording block

MEPs (M1) / unaltered auditory feedback / MEPs + retention tests at 24h

Evoked potentials will be recorded from brain area M1 (motor cortex) in combination with unaltered auditory feedback. Retention of learning will be tested 24h later along with additional evoked potential recordings.

Group Type EXPERIMENTAL

Adaptation baseline

Intervention Type BEHAVIORAL

Auditory baseline in speech

Motor evoked potentials

Intervention Type DEVICE

motor evoked potentials will be obtained in each recording block

AEPs (A1) / unaltered auditory feedback / AEPs + retention tests at 24h

Evoked potentials will be recorded from brain area A1 (auditory cortex) in combination with unaltered auditory feedback. Retention of learning will be tested 24h later along with additional evoked potential recordings.

Group Type EXPERIMENTAL

Adaptation baseline

Intervention Type BEHAVIORAL

Auditory baseline in speech

Auditory evoked potentials

Intervention Type DEVICE

auditory evoked potentials will be obtained in each recording block

SEPs (S1) / unaltered auditory feedback / SEPs + retention tests at 24h

Evoked potentials will be recorded from brain area S1 (somatosensory cortex) in combination with unaltered auditory feedback. Retention of learning will be tested 24h later along with additional evoked potential recordings.

Group Type EXPERIMENTAL

Adaptation baseline

Intervention Type BEHAVIORAL

Auditory baseline in speech

Somatosensory evoked potentials

Intervention Type DEVICE

Somatosensry evoked potentials will be obtained in each recording block

Interventions

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Adaptation

Auditory adaptation in speech

Intervention Type BEHAVIORAL

Adaptation baseline

Auditory baseline in speech

Intervention Type BEHAVIORAL

Motor evoked potentials

motor evoked potentials will be obtained in each recording block

Intervention Type DEVICE

Auditory evoked potentials

auditory evoked potentials will be obtained in each recording block

Intervention Type DEVICE

Somatosensory evoked potentials

Somatosensry evoked potentials will be obtained in each recording block

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Fluent English speakers
* Right-handed
* Normal hearing
* No speech disorder or reading disability

Exclusion Criteria

* Cardiac pacemaker
* Aneurysm clip
* Heart or Vascular clip
* Prosthetic valve
* Metal implants
* Metal in brain, skull, or spinal cord
* Implanted neurostimulator
* Medication infusion device
* Cochlear implant or tinnitus (ringing in ears)
* Personal and/or family history of epilepsy or other neurological disorders or history of head concussion
* Psychoactive medications
* Pregnancy

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes