Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
117 participants
INTERVENTIONAL
2024-02-15
2026-04-30
Brief Summary
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Detailed Description
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The entire study is composed of 8 experiments and 6 interventions. The present record represents Experiments 1-4: 1) Generalization of Vowel Space Expansion to Untrained Words and Vowels; 2) Retention of Vowel Space Expansion After Training in Multiple Sessions; 3) Vowel Space Expansion Training With Connected Speech, and 4)The Relationship Between Acuity, Variability, and Adaptation in Vowels. The paradigms in Experiments 1-3 all involve speech production under conditions of altered auditory feedback, while Experiment 4 is a correlative analysis that compares data from Experiments 1 and 2.
The Experiment 1 paradigm tests how the vowel space expansion induced by sensorimotor adaptation generalizes to untrained items in a single session. Participants will produce four training words (bead, bad, bod, and booed) under a vowel centralization feedback paradigm in which auditory feedback is altered, training them to produce these words with more vowel contrast. In addition to these trained words, eight test items will be produced in pre-training and post-training phases only. We will compare to measure how learning transfers across words that share the same vowel (test words: keep, cap, cop, coop) or whose vowels are intermediate to those of the trained words and which share consonants with the trained words (test words: bid, bud, bade, bode).
The Experiment 2 paradigm tests how the vowel space expansion induced by sensorimotor adaptation is retained over time. Participants will complete eight sessions of the vowel centralization sensorimotor adaptation paradigm over four weeks, producing four training words (bead, bad, bod, and booed) under conditions of altered auditory feedback that train them to produce these words with more vowel contrast. We will measure changes in produced vowels at the start of each session in a baseline phase to assess how much retained across days and weeks.
The Experiment 3 paradigm tests whether vowel space expansion can be evoked by a vowel centralization feedback paradigm applied to running speech (full sentences) rather than single words in healthy speakers. Participants will produce sentences from the Harvard corpus while their speech feedback is altered to centralize vowel feedback. The investigators will measure how working vowel space increases under this paradigm.
Experiment 4 is a correlative analysis which tests whether sensory acuity and speech production variability can predict magnitude of sensorimotor adaptation in interventions 1 and 2. Auditory acuity will be measured through a phoneme discrimination task in which vowel sounds are played to participants over headphones; somatosensory acuity will be measured through a tactile discrimination task in which participants report the orientation (horizontal or vertical) of the gratings on a plastic dome pressed lightly into the tongue. Speech production variability will be measured as the formant variability in the baseline phase of the sensorimotor adaptation experiments in interventions 1 and 2. These measures will be correlated with sensorimotor adaptation magnitude found in the prior interventions.
Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Healthy Adult Speakers
healthy adult participants across the lifespan in three groups:18-35, 36-55, and 56+
Exp 3 Speaking Task
Participant will sit in front of a computer screen in a quiet room and to produce speech based on what is on the screen. Participant may see real words or nonsense words to read. Investigators may play sounds through headphones and ask the participant to repeat them. Participant speech will be recorded by a microphone. This task takes about one hour to complete.
Interventions
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Exp 3 Speaking Task
Participant will sit in front of a computer screen in a quiet room and to produce speech based on what is on the screen. Participant may see real words or nonsense words to read. Investigators may play sounds through headphones and ask the participant to repeat them. Participant speech will be recorded by a microphone. This task takes about one hour to complete.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* normal hearing and speech
* no history of stroke or neurological conditions
Exclusion Criteria
* Any neurological disorders other than the disorder of interest
* Any history of hearing disorders
* Uncorrected vision problems that prevent participants from seeing visually-presented stimuli
* Significant cognitive impairments that prevent participants from carrying out the task or from giving informed consent
* Vulnerable populations (minors and prisoners)
18 Years
ALL
Yes
Sponsors
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National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
University of Wisconsin, Madison
OTHER
Responsible Party
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Principal Investigators
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Carrie Niziolek, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Wisconsin, Madison
Locations
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University of Wisconsin
Madison, Wisconsin, United States
Countries
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Central Contacts
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Facility Contacts
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Related Links
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Link to study record for experiment 7 \[NCT05723575\]
Link to study record for experiment 5 \[NCT05286658\]
Other Identifiers
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Protocol Version 10/31/2021
Identifier Type: OTHER
Identifier Source: secondary_id
A481800
Identifier Type: OTHER
Identifier Source: secondary_id
2017-1128 Adaptation (Exp 1-4)
Identifier Type: -
Identifier Source: org_study_id