Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
330 participants
INTERVENTIONAL
2024-10-01
2029-05-31
Brief Summary
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Detailed Description
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Aim 2 assesses the temporal order in which plasticity occurs in cortical motor and sensory brain areas during speech motor learning.
In Aim 3, resting-state fMRI will be interleaved with speech motor adaptation. For information specific to each aim, please refer to the below corresponding, separate, clinicaltrials.gov records: unique IDs: 2000037622\_a for Aim 1, 2000037622\_b for Aim 2 and 2000037622\_c for Aim 3.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Speech Motor Learning and Retention Aim 1
Aim 1: Participants will perform learning tasks while receiving altered/unaltered auditory feedback with cTBS applied to the appropriate area of the brain following learning. Retention of learning is assessed 24 hours later.
continuous theta-burst stimulation (cTBS)
cTBS stimulation will be applied to different areas of the brain following learning. Stimulation will take place following learning in order to block motor memory retention.
Adaptation
Auditory adaptation in speech
Speech Motor Learning and Retention Aim 2
Aim 2: Participants will perform learning tasks combined with shifted auditory feedback. Motor cortical excitability will be measured using single-pulse TMS to elicit motor evoked potentials.
Adaptation
Auditory adaptation in speech
Single pulse Transcranial magnetic stimulation (TMS)
TMS will be delivered 10 times in each motor evoked potentials (MEP) recording block.
Speech Motor Learning and Retention Aim 3
Aim 3: Participants will have fMRI with behavioral measures of speech motor learning.
Adaptation
Auditory adaptation in speech
fMRI
To assess functional connectivity patterns between regions that predict learning.
Interventions
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continuous theta-burst stimulation (cTBS)
cTBS stimulation will be applied to different areas of the brain following learning. Stimulation will take place following learning in order to block motor memory retention.
Adaptation
Auditory adaptation in speech
Single pulse Transcranial magnetic stimulation (TMS)
TMS will be delivered 10 times in each motor evoked potentials (MEP) recording block.
fMRI
To assess functional connectivity patterns between regions that predict learning.
Eligibility Criteria
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Inclusion Criteria
* Right-handed
* Normal hearing
* No speech disorder or reading disability
Exclusion Criteria
* Aneurysm clip
* Heart or Vascular clip
* Prosthetic valve
* Metal implants
* Metal in brain, skull, or spinal cord
* Implanted neurostimulator
* Medication infusion device
* Cochlear implant or tinnitus (ringing in ears)
* Personal and/or family history of epilepsy or other neurological disorders or history of head concussion
* Psychoactive medications
* Pregnancy
18 Years
40 Years
ALL
Yes
Sponsors
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National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Yale University
OTHER
Responsible Party
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Principal Investigators
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David Ostry
Role: PRINCIPAL_INVESTIGATOR
Yale University
Locations
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Yale Child Study Center
New Haven, Connecticut, United States
Countries
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Central Contacts
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Other Identifiers
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2000037622
Identifier Type: -
Identifier Source: org_study_id
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