Development of Electroencephalography (EEG) and Magnetoencephalography (MEG) Source Reconstruction With Fast Multipole Method

NCT ID: NCT06471244

Last Updated: 2025-05-28

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-01-01
• Study Completion Date: 2027-04-01

Brief Summary

The goal of this clinical trial is to learn if an advanced 256 dry electrode EEG cap augmented with MEG readings and coupled with a new high-resolution fast brain modeling software gives a better EEG and MEG source localization in real time. The main questions it aims to answer are:

• Does the testbed better localize brain sources for finger movement?
• Does the testbed better localize brain sources for median nerve stimulation?
• Does the testbed better localize brain sources for speech processing?
• Researchers will compare the predicted cortical locations with MEG data and known anatomical locations of the neuronal generators.

Participants will:

• Undergo Magnetic Resonance Imaging (MRI) scans for brain and head model creation
• Undergo three different EEG tests
• Undergo three different MEG tests

Detailed Description

Magnetic Resonance Imaging (MRI) head/neck scans of 30 healthy subjects using the 7 Tesla Siemens Scanner will be performed at the Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig Germany with 0.5/0.7 mm isotropic resolution, for both T1 and T2 imaging sequences. Construction of computational head models from the MRI data using FreeSurfer and Charm segmentation software packages will be performed at Worcester Polytechnic Institute.

On-skin voltage recordings will be done with 256 dry electrodes. Our EEG protocols will collect 240 trials per subject (3 runs of 80 trials each). German volunteers will be tapping with their right hand index finger. The corresponding neuronal generators are located in the M1INDEXFINGER/S1INDEXFINGER areas (primary motor/somatosensory cortex) at different latencies.

On-skin voltage recordings will be done with 256 dry electrodes. Our EEG protocols will collect 240 trials per subject (3 runs of 80 trials each). .Electrical stimuli over the median nerve at the right wrist will be delivered using brief transcutaneous pulses every 1.5 seconds. The task is to respond to each stimulus by pushing a button with the left-hand index finger. This generates EEG evoked responses in the S1HAND area (primary somatosensory cortex contralateral to the nerve stimuli), and the M1HAND area (primary motor cortex) at different latencies. The P20/N20 response peaking at about 20 ms is targeted, since at this latency its neuronal generators are well-known to be located in the posterior wall of the central sulcus in the Brodmann area 3b.

On-skin voltage recordings will be done with 256 dry electrodes. Our EEG protocols will collect 240 trials per subject (3 runs of 80 trials each). German sentences will be played to the volunteers and the volunteers have to fulfill a semantic task. This generates EEG evoked responses in the known areas of the Primary Auditory Cortex (PAC).

On-skin voltage recordings will be done with 256 dry electrodes. Our MEG protocols will collect 240 trials per subject (3 runs of 80 trials each). German volunteers will be tapping with their right hand index finger. The corresponding neuronal generators are located in the M1INDEXFINGER/S1INDEXFINGER areas (primary motor/somatosensory cortex) at different latencies.

On-skin voltage recordings will be done with 256 dry electrodes. Our MEG protocols will collect 240 trials per subject (3 runs of 80 trials each). Electrical stimuli over the median nerve at the right wrist will be delivered using brief transcutaneous pulses every 1.5 seconds. The task is to respond to each stimulus by pushing a button with the left-hand index finger. This generates MEG evoked responses in the S1HAND area (primary somatosensory cortex contralateral to the nerve stimuli), and the M1HAND area (primary motor cortex) at different latencies. The P20/N20 response peaking at about 20 ms is targeted, since at this latency its neuronal generators are well-known to be located in the posterior wall of the central sulcus in the Brodmann area 3b.

On-skin voltage recordings will be done with 256 dry electrodes. Our MEG protocols will collect 240 trials per subject (3 runs of 80 trials each). German sentences will be played to the volunteers and the volunteers have to fulfill a semantic task. This generates EEG evoked responses in the known areas of the Primary Auditory Cortex (PAC).

The main questions it aims to answer are:

Does the proposed high-resolution testbed better localize brain sources for finger movement?

Does the proposed high-resolution testbed better localize brain sources for median nerve stimulation?

Does the proposed high-resolution testbed better localize brain sources for speech processing?

Conditions

Healthy

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

EEG/MEG data collection and processing with high density recording techniques

Group Type: EXPERIMENTAL

Finger tapping

Intervention Type: OTHER

The volunteer is tapping with his/her right hand index finger.

Median nerve stimulation

Intervention Type: OTHER

Electrical pulses are applied at the wrist to the median nerve.

Speech processing

Intervention Type: OTHER

German sentences are played to the volunteers and the volunteers have to fulfill a semantic task.

Interventions

Finger tapping

The volunteer is tapping with his/her right hand index finger.

Intervention Type: OTHER

Median nerve stimulation

Electrical pulses are applied at the wrist to the median nerve.

Intervention Type: OTHER

Speech processing

German sentences are played to the volunteers and the volunteers have to fulfill a semantic task.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Age at least 18 and less than 66 years
• Normal hearing and (corrected) vision
• Able to understand and give informed consent

Exclusion Criteria

• Cardiac pacemaker or pacemaker wires; neurostimulators; implanted pumps
• Metal in the body (rods, plates, screws, shrapnel, dentures, IUD) or metallic particles in the eye
• Surgical clips in the head or previous neurosurgery
• Any magnetic particles in the body
• Cochlear implants
• Prosthetic heart valves
• History of skull injury or defects
• Significant claustrophobia; Ménière's disease
• Pregnancy, breast feeding
• Neurological or psychiatric diagnoses or medications influencing brain function
• Current substance abuse (exception: concurrent nicotine use is allowed)
• Failure to perform the behavioral tasks or psychological evaluation tests
• Prisoners

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Technische Universität Ilmenau

UNKNOWN

Sponsor Role: collaborator

Max Planck Institute for Human Cognitive and Brain Sciences

OTHER

Sponsor Role: collaborator

Worcester Polytechnic Institute

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Sergey N Makaroff, PhD

Role: PRINCIPAL_INVESTIGATOR

Worcester Polytechnic Institute

Locations

Technical University Ilmenau

Ilmenau, , Germany

Site Status: RECRUITING

Max-Planck-Institut für Kognitions- und Neurowissenschaften [Cognitive and Neuroscience]

Leipzig, , Germany

Site Status: RECRUITING

Countries

Germany

Central Contacts

Sergey N Makaroff, PhD

Role: CONTACT

snmakaroff@wpi.edu

508-831-5017

Facility Contacts

Jens Haueisen, PhD

Role: primary

jens.haueisen@tu-ilmenau.de

+49 (0) 3677 69-2860

Burkhard Maess, PhD

Role: primary

maess@cbs.mpg.de

+49 341 9940-2526

Other Identifiers

24-0779

Identifier Type: -

Identifier Source: org_study_id