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Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in Electrophysiological (EP) Study

NCT ID: NCT00176176

Last Updated: 2006-10-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Brief Summary

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In this study, changes in electroencephalogram (EEG) and the hemodynamic state during ventricular fibrillation or induced ventricular tachycardia are investigated.

Detailed Description

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Patients with a high risk of malignant tachyarrhythmia are routinely investigated by programmed electrophysiological study (EPS). To investigate the hemodynamic effects of ventricular arrhythmia to cerebral circulation an EEG and transcranial ultrasound are conducted simultaneously during the EPS. Before and after the EPS a neuropsychological test and an investigation of a specific blood sample (Neuron Specific Enolase, NSE) is done.

Conditions

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Ventricular Fibrillation Ventricular Tachycardia

Keywords

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cerebral circulation

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Interventions

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EEG

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 years
* Positive agreement
* EPS for primary and secondary prophylaxis of a malignant ventricular tachyarrhythmia:

* primary prophylaxis: Brugada syndrome, long QT syndrome, cardiomyopathy, short QT syndrome
* secondary prophylaxis: Multicenter Automatic Defibrillator Implantation Trial (MADIT) criteria, syncope, documented ventricular tachycardia

Exclusion Criteria

* Severe neurological deficit
* Cardiopulmonary resuscitation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Heidelberg University

OTHER

Sponsor Role lead

Principal Investigators

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Martin Borggrefe, Prof., MD

Role: STUDY_DIRECTOR

I.Medizinische Klinik, Universitätsklinikum Mannheim

M Hennerici, Prof., MD

Role: STUDY_DIRECTOR

Neurologische Klinik Universitätsklinikum Mannheim

Locations

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Fakultät für Klinische Medizin Mannheim Universitätsklinikum Mannheim der Ruprecht-Karls-Universität Heidelberg

Mannheim, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Christian Wolpert, PD, MD

Role: CONTACT

Phone: +49-621-383-2206

Email: [email protected]. uni-heidelberg.de

Facility Contacts

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Christian Wolpert, PD, MD

Role: primary

Other Identifiers

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235/04

Identifier Type: -

Identifier Source: org_study_id