Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
30 participants
INTERVENTIONAL
2024-08-01
2026-07-01
Brief Summary
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Different iTBS stimulation parameters can be used to induce plasticity. This study will focus on two parameters, namely, the form and duration of the electromagnetic stimulation. The shape of the electromagnetic pulse refers to how the electromagnetic wave is configured over time, while the duration is simply the period during which this electromagnetic pulse remains active. These parameters are expected to influence the effectiveness of iTBS in modulating cortical activity but remain little studied.
The main aim of this study will be to compare the effectiveness of different stimulation parameters in the induction of plasticity, which will then make it possible to improve the rTMS protocols used for treatment-resistant depression.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Intermittent theta burst stimulation (iTBS)
All participants will understand 3 different iTBS protocols, each separated by one week. The order of the iTBS protocols will be randomized.
Monophasic iTBS
iTBS protocol with monophasic-shaped pulses. iTBS parameters:
* Intensity: 80% of resting motor threshold (rMT)
* Frequency: 50 Hz
* Duration of pulse train: 2 seconds
* Interval between pulse trains: 8 seconds
Biphasic iTBS
iTBS protocol with biphasic-shaped pulses. iTBS parameters:
* Intensity: 80% of rMT
* Frequency: 50 Hz
* Duration of pulse train: 2 seconds
* Interval between pulse trains: 8 seconds
Monophasic-Long iTBS
iTBS protocol with long monophasic-shaped pulses. iTBS parameters:
* Intensity: 80% of rMT
* Frequency: 50 Hz
* Duration of pulse train: 2 seconds
* Interval between pulse trains: 8 seconds
Interventions
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Monophasic iTBS
iTBS protocol with monophasic-shaped pulses. iTBS parameters:
* Intensity: 80% of resting motor threshold (rMT)
* Frequency: 50 Hz
* Duration of pulse train: 2 seconds
* Interval between pulse trains: 8 seconds
Biphasic iTBS
iTBS protocol with biphasic-shaped pulses. iTBS parameters:
* Intensity: 80% of rMT
* Frequency: 50 Hz
* Duration of pulse train: 2 seconds
* Interval between pulse trains: 8 seconds
Monophasic-Long iTBS
iTBS protocol with long monophasic-shaped pulses. iTBS parameters:
* Intensity: 80% of rMT
* Frequency: 50 Hz
* Duration of pulse train: 2 seconds
* Interval between pulse trains: 8 seconds
Eligibility Criteria
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Inclusion Criteria
* Be of right manual dominance
* In good health
Exclusion Criteria
* Having tinnitus,
* Have a history of fainting,
* Have already had an epileptic seizure or have a family history of epilepsy,
* Have a known neurological disease,
* Be under psychotropic medication,
* Have suffered from substance abuse or dependence in the last 6 months,
* Have a neurostimulator,
* Have a splinter or metallic implant in the head or the rest of the body,
* Have a cochlear implant,
* Have an automated injection system implanted (insulin pump),
* Have a transdermal patch,
* Have tattoos in the area to be studied,
* Be pregnant or breastfeeding,
18 Years
35 Years
ALL
Yes
Sponsors
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Université de Sherbrooke
OTHER
Responsible Party
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Jean-François Lepage
Full professor, Department of Pediatrics
Locations
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Centre de recherche du Centre hospitalier universitaire de Sherbrook
Sherbrooke, Quebec, Canada
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2024-5470
Identifier Type: -
Identifier Source: org_study_id
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