Transcranial Magnetic Treatment (TMS) in Unipolar Depression

NCT ID: NCT00186784

Last Updated: 2011-08-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2000-12-31

Study Completion Date

2011-07-31

Brief Summary

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Repetitive Transcranial Magnetic Stimulation (rTMS) can improve mood and decrease sadness in patients with depression.

In this study, the investigators seek to increase their understanding about how rTMS improves depression, and to determine which form of rTMS is most effective for depression, when used in combination with antidepressant medication.

Detailed Description

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Patients will be assigned for 4 treatment arms, receiving either left high frequency plus right low frequency, or left high frequency plus right sham, or left sham, plus right low frequency, or left sham plus right sham treatment. All subjects will receive treatments for 10 days and will be followed for another 4 weeks.

Conditions

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Unipolar Depression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Interventions

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Transcranial Magnetic Stimulation (TMS)

treatment for 10 days

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Major Depression
* No physical health problems

Exclusion Criteria

* History of Epilepsy
* Metal in the head/neck or skull
* Pacemaker
* Pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Queen's University, Kingston, Ontario

OTHER

Sponsor Role collaborator

St. Joseph's Healthcare Hamilton

OTHER

Sponsor Role lead

Responsible Party

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St. Joseph's Healthcare

Principal Investigators

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Gary Hasey, MD

Role: PRINCIPAL_INVESTIGATOR

McMaster University

Locations

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St.Joseph's Healthcare, rTMS Laboratory, Mood Disorders Program, 100 West Fifth Street

Hamilton, Ontario, Canada

Site Status

Countries

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Canada

References

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Jacquot F, Khoury S, Labrum B, Delanoe K, Pidoux L, Barbier J, Delay L, Bayle A, Aissouni Y, Barriere DA, Kultima K, Freyhult E, Hugo A, Kosek E, Ahmed AS, Jurczak A, Lingueglia E, Svensson CI, Breuil V, Ferreira T, Marchand F, Deval E. Lysophosphatidylcholine 16:0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3. Pain. 2022 Oct 1;163(10):1999-2013. doi: 10.1097/j.pain.0000000000002596. Epub 2022 Jan 27.

Reference Type DERIVED
PMID: 35086123 (View on PubMed)

Other Identifiers

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TMS1871

Identifier Type: -

Identifier Source: org_study_id

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