Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
80 participants
INTERVENTIONAL
2024-10-31
2028-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
SINGLE
Study Groups
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Active iTBS for Patients With MCI or AD
The patient will receive one daily rTMS session for 10 days of iTBS, delivered through an H-coil applied to the left dorsolateral prefrontal cortex. The TBS frequency parameters consist of 3-pulse 50-Hz bursts every 200 ms at 5 Hz, and the intensity will be set at 80% of the active motor threshold (AMT). A single session of iTBS contains 2 s of TBS repeated every 10 s for 20 times.
Active rTMS
iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total10 sessions
Sham iTBS for Patients With MCI or AD
Sham stimulation will be delivered 10 sessions.
Sham rTMS
sham iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total 10 sessions
Interventions
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Active rTMS
iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total10 sessions
Sham rTMS
sham iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total 10 sessions
Eligibility Criteria
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Inclusion Criteria
* Clinical diagnosis of mild Alzheimer's Disease (overall Clinical Dementia Rating of 0.5 or 1)
Exclusion Criteria
* History of uncontrol seizure
* History of significant head trauma followed by persistent neurologic deficit or known structural brain abnormality
* Mental illness
* Drug abuse
50 Years
85 Years
ALL
No
Sponsors
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National Defense Medical Center, Taiwan
OTHER
Responsible Party
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Yu-Kai Lin
Tri-Service General Hospital
Locations
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Tri-Service General Hospital
Taipei, Other, Taiwan
Countries
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Central Contacts
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Facility Contacts
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Role: backup
References
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Daskalakis ZJ. Theta-burst transcranial magnetic stimulation in depression: when less may be more. Brain. 2014 Jul;137(Pt 7):1860-2. doi: 10.1093/brain/awu123. Epub 2014 May 15. No abstract available.
Huang YZ, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC. Theta burst stimulation of the human motor cortex. Neuron. 2005 Jan 20;45(2):201-6. doi: 10.1016/j.neuron.2004.12.033.
Related Links
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Related Info
Other Identifiers
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A202305164
Identifier Type: -
Identifier Source: org_study_id
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