Demineralized Dentin Allograft Versus Demineralized Dentin Autograft for Socket Preservation

NCT ID: NCT06457373

Last Updated: 2025-11-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-12-30

Study Completion Date

2026-12-30

Brief Summary

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This study is designed to evaluate and compare clinically and radiographically the effectiveness of Demineralized Dentin Allograft (DDA) versus Demineralized Dentin Autograft (Auto-DD) for preservation of alveolar ridge dimensions after surgical extraction of the impacted mandibular third molar.

Detailed Description

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Conditions

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Alveolar Bone Loss

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

20 sockets will be grafted with Demineralized Dentin Allograft (DDA) and 20 sockets will be grafted with Demineralized Dentin Autograft (Auto-DD)
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Group A

20 sockets will be grafted with Demineralized Dentin Allograft (DDA)

Group Type EXPERIMENTAL

Demineralized Dentin Allograft

Intervention Type PROCEDURE

20 sockets are randomly allocated to receive the Demineralized Dentin Allograft (split-mouth study)

Group B

20 sockets will be grafted with Demineralized Dentin Autograft (Auto-DD)

Group Type ACTIVE_COMPARATOR

Demineralized Dentin Autograft

Intervention Type PROCEDURE

20 sockets are randomly allocated to receive the Demineralized Dentin Autograft (split-mouth study)

Interventions

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Demineralized Dentin Allograft

20 sockets are randomly allocated to receive the Demineralized Dentin Allograft (split-mouth study)

Intervention Type PROCEDURE

Demineralized Dentin Autograft

20 sockets are randomly allocated to receive the Demineralized Dentin Autograft (split-mouth study)

Intervention Type PROCEDURE

Other Intervention Names

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DDA Auto-DD

Eligibility Criteria

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Inclusion Criteria

1. Patients aged between 25 to 35 years old.
2. Patients scored as (ASA I).
3. No adverse habits such as smoking, tobacco chewing, alcohol.
4. Patients having bilaterally impacted mandibular third molar with similar degree of difficulty according to (Kim JY, et al).
5. The recipient alveolar sockets are free of any pre-existing periapical pathology, based on x-ray.
6. Alveolar sockets with a depth of 5 mm or more, using periodontal probe for assessment.
7. Patients sign a consent for all procedures.

Exclusion Criteria

* 1\) Pregnant or lactating patients. 2) Relevant systemic diseases. 3) Patients with history of chemotherapy or radiotherapy.
Minimum Eligible Age

25 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Horus University

OTHER

Sponsor Role lead

Responsible Party

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Mohamed Ali Habib

Oral and maxillofacial surgery clinical demonstrator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mohamed Habib, B.D.S

Role: PRINCIPAL_INVESTIGATOR

Faculty of Dentistry- Horus University in Egypt

Ahmed Khalil

Role: STUDY_DIRECTOR

Faculty of Dentistry- Horus University in Egypt

Eman Abdelsalam

Role: STUDY_DIRECTOR

Faculty of Dentistry- Horus University in Egypt

Locations

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Faculty of Dentistry- Horus University in Egypt

Damietta, New-Damietta, Egypt

Site Status

Countries

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Egypt

Central Contacts

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Mohamed Habib, B.D.S

Role: CONTACT

+2001069505336

Ahmed Khalil, PHD

Role: CONTACT

+2001005062045

Facility Contacts

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Mohamed Habib, B.D.S

Role: primary

+2001069505336

References

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Joshi CP, D'Lima CB, Samat UC, Karde PA, Patil AG, Dani NH. Comparative Alveolar Ridge Preservation Using Allogenous Tooth Graft versus Free-dried Bone Allograft: A Randomized, Controlled, Prospective, Clinical Pilot Study. Contemp Clin Dent. 2017 Apr-Jun;8(2):211-217. doi: 10.4103/ccd.ccd_147_17.

Reference Type BACKGROUND
PMID: 28839405 (View on PubMed)

Grover V, Kapoor A, Malhotra R, Sachdeva S. Bone allografts: a review of safety and efficacy. Indian J Dent Res. 2011 May-Jun;22(3):496. doi: 10.4103/0970-9290.87084.

Reference Type BACKGROUND
PMID: 22048602 (View on PubMed)

Other Identifiers

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(DDA) for socket preservation

Identifier Type: -

Identifier Source: org_study_id

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