Primary Immunodeficiencies and Obstetrical Neuraxial Anaesthesia

NCT ID: NCT06449066

Last Updated: 2025-09-12

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-08-08
• Study Completion Date: 2024-08-20

Brief Summary

The purpose of this study is to evaluate if neuraxial anesthesia (epidural or intradural anesthesia) used during childbirth is associated with more frequent infectious complications in patients with primary immunodeficiencies (PID).

Detailed Description

Neuraxial anaesthesia (epidural or intradural) is often used to alleviate pain during labour and childbirth. Although extremely efficient and safe, rare but serious infectious complications such as epidural abscess or meningitis can occur afterwards.

Patients with PID tend to have a greater risk of infectious complications than the general population. With the progress of medical care in those pathologies, female patients are now giving birth more often. The use of neuraxial anaesthesia and the associated infectious complications have never been studied in this population.

The investigators intend to review the medical records of PID patients who gave birth in an APHP hospital in the last 10 years to evaluate the use of neuraxial anesthesia and the frequency of infectious complications associated with neuraxial anesthesia.

Conditions

Infectious Complications (Epidural Abscess or Meningitis); Obstetrical Neuraxial Anaesthesia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Patients

CEREDIH (centre de reference des deficits immunitaires héréditaires) cohort Female patients, alive and \> 18 years old, registered at the CEREDIH who gave birth in an APHP maternity

Non applicable

Intervention Type: OTHER

Non applicable (data collection)

Interventions

Non applicable

Non applicable (data collection)

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Female patient included in the CEREDIH national register
• Aged > 18 years

Exclusion Criteria

• Refuse to participate
• Deceased
• Minor
• under judicial protection
• obstetric file not available

• Minimum Eligible Age: 18 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

URC-CIC Paris Descartes Necker Cochin

OTHER

Sponsor Role: collaborator

Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Caroline Charlier-Woerther

Role: PRINCIPAL_INVESTIGATOR

APHP

Locations

Infectiology mobile team - Department of Infectious and Tropical Diseases

Paris, Île-de-France Region, France

Countries

France

References

Beloeuvre A, Anselem O, Tazi A, Keita-Meyer H, Mahlaoui N, Charlier C. Anesthetic management of women with primary immunodeficiencies in the obstetric setting: A French cohort study (ANEU-DIP). J Allergy Clin Immunol Glob. 2025 Jan 30;4(2):100433. doi: 10.1016/j.jacig.2025.100433. eCollection 2025 May.

Reference Type: BACKGROUND

PMID: 40226770 (View on PubMed)

Other Identifiers

APHP240481

Identifier Type: -

Identifier Source: org_study_id