Portal Vein Pulsatility Index to Assess Fluid Intolerance

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-05-01

Study Completion Date

2024-07-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study uses the portal vein pulsatility index (PVPI) to assess fluid intolerance amongst fluid responders.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility

NCT04089098

Hemodynamic Instability Shock Septic Shock

COMPLETED

Response of Pulse Pressure Variation in PA Catheter Tracing to IV Fluid Bolus in the ICU

NCT02419404

Hypovolemia

COMPLETED

Volume Kinetics of Fluid Resuscitation in Early Sepsis

NCT06499701

Fluid and Electrolyte Imbalance

RECRUITING

Changes in PPV Induced by PLR Test to Predict Fluid Responsiveness in ICU

NCT03225378

Acute Circulatory Failure

COMPLETED

Inferior Vena Cava Collapsibility Index Guide for Preoperative Fluid Therapy in Preeclampsia

NCT06539026

Pre-Eclampsia Hypotension Fluid Overload

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This prospective observational study aims to use the portal vein pulsatility index (PVPI) to assess fluid intolerance in fluid responders. The investigators will enroll mechanically ventilated postoperative adult patients within 6 hours of ICU admission after cardiac surgery. Patients will undergo a Passive Leg Raising (PLR) test and Left Ventricular Outflow Tract (LVOT) recording using transthoracic echocardiography. The main objective is to predict fluid intolerance after a fluid challenge of 7 ml/kg Ringer Lactate over 10 minutes in initially tolerant fluid responders.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Venous Congestion

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Tolerant Fluid Responders

Patients who are both responsive and tolerant to fluid.

Ringer's Lactate Crystalloid Solutions

Intervention Type DRUG

7 ml/kg ml of Ringer's Lactate is given in 10 min amongst initially tolerant fluid responders.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Ringer's Lactate Crystalloid Solutions

7 ml/kg ml of Ringer's Lactate is given in 10 min amongst initially tolerant fluid responders.

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Fluid challenge

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Informed consent.
* Mechanically ventilated patients within 6 hours after ICU admission following surgery who are considered for fluid administration to optimize haemodynamics.
* Sinus rhythm.

Exclusion Criteria

* A condition known to interfere with portal vein flow assessment or interpretation (liver cirrhosis or chronic hepatic disease, suprahepatic or portal vein thrombosis).
* Any mechanical circulatory support.
* Cardiac transplant.
* Poor transthoracic echocardiographic window.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No