Uterine Artery Diastolic Notching & Apelin-13 and 36

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

88 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-03-01

Study Completion Date

2024-01-01

Brief Summary

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This study was conducted to investigate the relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and 36 concentrations between 11 and 14 weeks of gestation.

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Detailed Description

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Apelin-13 and apelin-36, which provide vasodilatation through a nitric oxide-dependent mechanism, also play a role in trophoblasts' survival, proliferation, and migration.

Based on this, we aimed to investigate serum apelin-13 and apelin-36 concentrations in pregnant women with and without diastolic notch on uterine artery Doppler between the 11th and 14th weeks of pregnancy.

We hypothesized that apelin-13 and apelin-36 might be associated with the formation of diastolic notch in uterine artery Doppler and serum apelin-13 and apelin-36 concentrations would be lower in the group with a notch in the uterine artery Doppler than in the group without a notch.

Conditions

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Diagnosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Uterine artery notch negative group

Pregnant women who did not have diastolic notching in uterine artery Doppler between the 11th and 14th weeks of pregnancy constituted the uterine artery notch negative group.

no intervention

Intervention Type OTHER

there is no intervention in this study

Uterine artery notch positive group

Pregnant women with unilateral or bilateral diastolic notching detected in uterine artery Doppler between the 11th and 14th weeks of pregnancy formed the uterine artery notch positive group.

no intervention

Intervention Type OTHER

there is no intervention in this study

Interventions

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no intervention

there is no intervention in this study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Nonsmokers,
2. Singleton pregnancies between 11 and 14 weeks of gestation
3. Pregnant women who did not conceive with assisted reproductive methods

Exclusion Criteria

1. Smokers
2. Pregnant women who conceived with assisted reproductive techniques
3. Pregnant women with multiple pregnancies
4. Pregnant women who started with multiples and continued with singletons
5. Pregnant women with any pregestational disease, thrombophilia
6. Pregnant women with any congenital uterine anomaly
7. Pregnant women with a history of recurrent pregnancy loss
8. Pregnant women using aspirin or heparin

Minimum Eligible Age

18 Years

Maximum Eligible Age

39 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes