Neurofeedback-Based Digital Therapeutics for the Diagnosis and Treatment of ADHD in Children.

NCT ID: NCT06369714

Last Updated: 2025-06-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

210 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-24

Study Completion Date

2025-12-31

Brief Summary

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A multi-center, randomized controlled trial is being conducted to investigate the efficacy of a novel digital therapeutics (DTx) program that utilizes a cross-training approach between neurofeedback training and executive function training for pediatric patients (aged 6-12) diagnosed with ADHD. This gamified interactive program is designed to improve attention deficits and executive function impairments in pediatric patients with ADHD. It is delivered through an engaging iPad game in a home-based treatment format. Patients will be randomly assigned to one of three groups: medication alone, digital therapeutics alone, or a combination of both interventions. Subjects will undergo 30 treatment sessions over the 8-week period, with each session lasting 30 minutes. Investigators will reassess symptoms of ADHD, executive functions, and objective measures of attention at the end of the treatment. Additionally, questionnaires will be distributed to parents to gather their insights and feedback on the treatment approach. This innovative digital therapeutics approach is expected to improve ADHD symptoms individually and enhance therapeutic outcomes when used alongside conventional drug treatment regimens.

Detailed Description

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Conditions

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Attention Deficit Disorder With Hyperactivity Executive Function Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Medication group

The medication group will take Methylphenidate Hydrochloride Extended-Release Tablets with a fixed dose for eight weeks.

Group Type ACTIVE_COMPARATOR

Concerta

Intervention Type DRUG

Methylphenidate Hydrochloride Extended-Release Tablets with the following specifications: 18mg dosage, oral administration, once a day for a duration of 8 weeks.

Digital therapeutics group

The digital therapeutics group will complete 30 training sessions within 8 weeks.

Group Type EXPERIMENTAL

Digital therapeutics

Intervention Type DEVICE

30 sessions of digital therapeutics, each lasting 30 minutes, will be conducted with a frequency of once every 1-2 days over an 8-week period.

Combination group

The combination group will take Methylphenidate Hydrochloride Extended-Release Tablets while undergoing digital therapeutics.

Group Type EXPERIMENTAL

Concerta

Intervention Type DRUG

Methylphenidate Hydrochloride Extended-Release Tablets with the following specifications: 18mg dosage, oral administration, once a day for a duration of 8 weeks.

Digital therapeutics

Intervention Type DEVICE

30 sessions of digital therapeutics, each lasting 30 minutes, will be conducted with a frequency of once every 1-2 days over an 8-week period.

Interventions

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Concerta

Methylphenidate Hydrochloride Extended-Release Tablets with the following specifications: 18mg dosage, oral administration, once a day for a duration of 8 weeks.

Intervention Type DRUG

Digital therapeutics

30 sessions of digital therapeutics, each lasting 30 minutes, will be conducted with a frequency of once every 1-2 days over an 8-week period.

Intervention Type DEVICE

Other Intervention Names

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Methylphenidate Hydrochloride Extended-Release Tablets

Eligibility Criteria

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Inclusion Criteria

* Meet the diagnostic criteria established by the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) for ADHD.
* Digital Cancellation Test total score\<50 points.
* Raven's Standard Progressive Matrices score≥85.
* 6 years ≤ Age\<12 years.
* No interventions for ADHD received within 4 weeks.
* No color blindness.

Exclusion Criteria

* Patients with organic mental disorders, schizophrenia, bipolar disorder, depressive disorders, and other psychiatric conditions.
* Patients with comorbid autism spectrum disorder, Tourette's syndrome, and other neurodevelopmental disorders.
* Patients with comorbid conduct disorders.
* Patients with severe traumatic brain injury or neurological disorders.
* Patients with a history of severe somatic diseases.
* Patients with a history of substance or drug dependency.
Minimum Eligible Age

6 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Lei Lei, MD

OTHER

Sponsor Role lead

Responsible Party

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Lei Lei, MD

Associate Chief Physician, Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Lei Lei, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Pediatric, Changhai Hospital, Naval Medical University

Locations

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Changzheng Hospital, Naval Medical University

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Changhai Hospital, Naval Medical University

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Yuanhao Cai, MBBS

Role: CONTACT

15001969690

Lei Lei, MD

Role: CONTACT

13916072205

Facility Contacts

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Yujiao Wang, MBBS

Role: primary

15021500051

Yuanhao Cai, MBBS

Role: primary

15001969690

Other Identifiers

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CHEC2023-296

Identifier Type: -

Identifier Source: org_study_id

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