Mechanism Study of Ventilator-Induced Lung Injury in Elderly People.
NCT ID: NCT06367946
Last Updated: 2024-04-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
1000 participants
OBSERVATIONAL
2023-06-01
2027-06-30
Brief Summary
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2. We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelial/epithelial damage, age and duration of mechanical ventilation.
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Detailed Description
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2. We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelial/epithelial damage, age and duration of mechanical ventilation. All clinical samples have been collected and tested uniformly. Correlation analysis between endothelial/epithelial damage index, age and duration of mechanical ventilation will be performed by using SPSS 22.0 software, and P\<0.05 indicates a statistically significant difference. The obtained clinical data should be recorded on survey forms, and researchers should verify patient information by recording basic information such as age and gender.
Conditions
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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Under 40 years old
Patients undergoing surgery with mechanical ventilation who are under 40 years old
mechanical ventilation
Mechanical ventilation is machine-delivered flow of gases to both oxygenate and ventilate a patient who is unable to maintain physiological gas exchange.
40-50 years old
Patients undergoing surgery with mechanical ventilation who are 40-50 years old
mechanical ventilation
Mechanical ventilation is machine-delivered flow of gases to both oxygenate and ventilate a patient who is unable to maintain physiological gas exchange.
50-60 years old
Patients undergoing surgery with mechanical ventilation who are 50-60 years old
mechanical ventilation
Mechanical ventilation is machine-delivered flow of gases to both oxygenate and ventilate a patient who is unable to maintain physiological gas exchange.
60-70 years old
Patients undergoing surgery with mechanical ventilation who are 60-70 years old
mechanical ventilation
Mechanical ventilation is machine-delivered flow of gases to both oxygenate and ventilate a patient who is unable to maintain physiological gas exchange.
70-80 years old
Patients undergoing surgery with mechanical ventilation who are 70-80 years old
mechanical ventilation
Mechanical ventilation is machine-delivered flow of gases to both oxygenate and ventilate a patient who is unable to maintain physiological gas exchange.
Over 80 years old
Patients undergoing surgery with mechanical ventilation who are over 80 years old
mechanical ventilation
Mechanical ventilation is machine-delivered flow of gases to both oxygenate and ventilate a patient who is unable to maintain physiological gas exchange.
Interventions
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mechanical ventilation
Mechanical ventilation is machine-delivered flow of gases to both oxygenate and ventilate a patient who is unable to maintain physiological gas exchange.
Eligibility Criteria
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Inclusion Criteria
Patients undergoing elective general anesthesia surgery; Patients undergoing partial lung resection with mechanical ventilation; American Society of Anesthesiology (ASA) grade 2-3;
2. Peripheral blood from patients with different ages and duration of mechanical ventilation:
Patients undergoing elective general anesthesia surgery with mechanical ventilation; ASA grade 2-3;
Exclusion Criteria
Patients with chronic lung diseases (asthma, chronic obstructive pulmonary disease (COPD), pulmonary heart disease, etc.); Patients with human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.
2. Peripheral blood from patients with different ages and duration of mechanical ventilation:
Patients with chronic lung diseases (asthma, COPD, pulmonary heart disease, etc.); Smoking patients; Patients with hypertension/diabetes/coronary heart disease; Patients with HIV, HBV, HCV, HDV, or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.
ALL
No
Sponsors
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Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
OTHER
Responsible Party
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Lai Jiang
021-25077820
Principal Investigators
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Lai Jiang, PhD
Role: PRINCIPAL_INVESTIGATOR
Department of Anesthesia, Shanghai Xinhua hospital, Shanghai China
Locations
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Shanghai Xinhua hospital
Shanghai, , China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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XH-24-0093
Identifier Type: -
Identifier Source: org_study_id
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