Optimizing the Management of Staphylococcus Aureus Bacteremia (OPTIMUS-SAB)
NCT ID: NCT06338176
Last Updated: 2025-07-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
1800 participants
INTERVENTIONAL
2024-05-01
2026-04-30
Brief Summary
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Leveraging this pilot work, the investigators aim to implement OPTIMUS-SAB, an enhanced model of the pilot, to optimize and standardize SAB management across Alberta. The implementation study will be a zone-based acute care site stepped wedge design. OPTIMUS-SAB will consist of a centralized SAB care team whom will receive automated notification of all blood cultures positive for S. aureus allowing them to review the patient's medical chart and make preliminary management recommendations according to an evidence-based care bundle.
The investigators will evaluate adherence to evidence-based SAB quality-of-care indicators before and after OPTIMUS-SAB implementation and expect this to improve with a resultant reduction in duration of bacteremia, length of stay, readmission rates, and mortality. In turn, this will translate into cost savings for the health care system.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
SEQUENTIAL
HEALTH_SERVICES_RESEARCH
NONE
Study Groups
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OPTIMUS-SAB care pathway
Province-wide real time automated notifications of new SAB cases will be established and delivered to a centralized SAB care team electronically through Connect Care. The centralized SAB care team consists of a SAB clinical coordinator, ID specialists and other ad hoc representation depending on patient needs. Following patient chart review, the centralized SAB care team contacts the most responsible physician (MRP) to provide preliminary recommendations to optimize care, both verbally and in written format, facilitated by Connect Care (Alberta Health Services electronic medical record).
OPTIMUS-SAB clinical care pathway
Activation of SAB clinical care pathway within EMR system.
Standard of care
No interventions assigned to this group
Interventions
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OPTIMUS-SAB clinical care pathway
Activation of SAB clinical care pathway within EMR system.
Eligibility Criteria
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Inclusion Criteria
* Confirmed S. aureus bacteremia by blood culture performed at a laboratory in Alberta, Canada
* Admitted to a designated acute care site in Alberta, Canada
Exclusion Criteria
* GCD are C-level within 48 hours of admission.
* The patient is transferred in from an out-of-province acute care center with a pre-existing SAB diagnosis.
18 Years
ALL
No
Sponsors
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Alberta Health services
OTHER
University of Alberta
OTHER
Responsible Party
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Principal Investigators
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Justin Chen, MD
Role: PRINCIPAL_INVESTIGATOR
University of Alberta
Locations
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Athabasca Healthcare Centre
Athabasca, Alberta, Canada
Mineral Springs Hospital
Banff, Alberta, Canada
Barrhead Healthcare Centre
Barrhead, Alberta, Canada
Bassano Health Centre
Bassano, Alberta, Canada
Beaverlodge Municipal Hospital
Beaverlodge, Alberta, Canada
Oilfields General Hospital
Black Diamond, Alberta, Canada
Bonnyville Healthcare Centre
Bonnyville, Alberta, Canada
Bow Island Health Centre
Bow Island, Alberta, Canada
Boyle Healthcare Centre
Boyle, Alberta, Canada
Brooks Health Centre
Brooks, Alberta, Canada
Arthur J.E. Child Comprehensive Cancer Centre
Calgary, Alberta, Canada
Foothills Medical Centre
Calgary, Alberta, Canada
Peter Lougheed Centre
Calgary, Alberta, Canada
South Health Campus
Calgary, Alberta, Canada
Tom Baker Cancer Centre
Calgary, Alberta, Canada
St. Mary's Hospital
Camrose, Alberta, Canada
Canmore General Hospital
Canmore, Alberta, Canada
Cardston Health Centre
Cardston, Alberta, Canada
Our Lady of the Rosary Hospital
Castor, Alberta, Canada
Claresholm General Hospital
Claresholm, Alberta, Canada
Coaldale Health Centre
Coaldale, Alberta, Canada
Cold Lake Healthcare Centre
Cold Lake, Alberta, Canada
Consort Hospital and Care Centre
Consort, Alberta, Canada
Coronation Hospital and Care Centre
Coronation, Alberta, Canada
Crowsnest Pass Health Centre
Crowsnest Pass, Alberta, Canada
Daysland Health Centre
Daysland, Alberta, Canada
Devon General Hospital
Devon, Alberta, Canada
Didsbury District Health Services
Didsbury, Alberta, Canada
Drayton Valley Hospital and Care Centre
Drayton Valley, Alberta, Canada
Drumheller Health Centre
Drumheller, Alberta, Canada
Cross Cancer Institute
Edmonton, Alberta, Canada
Glenrose Rehabilitation Hospital
Edmonton, Alberta, Canada
Grey Nuns Community Hospital
Edmonton, Alberta, Canada
Misericordia Community Hospital
Edmonton, Alberta, Canada
Royal Alexandra Hospital
Edmonton, Alberta, Canada
University of Alberta Hospital
Edmonton, Alberta, Canada
Edson Healthcare Centre
Edson, Alberta, Canada
Elk Point Healthcare Centre
Elk Point, Alberta, Canada
Fairview Health Complex
Fairview, Alberta, Canada
Northern Lights Regional Health Centre
Fort McMurray, Alberta, Canada
St. Theresa General Hospital
Fort Vermilion, Alberta, Canada
Fox Creek Healthcare Centre
Fox Creek, Alberta, Canada
Fort Saskatchewan Community Hospital
Ft Saskatchewan, Alberta, Canada
Grande Cache Community Health Complex
Grande Cache, Alberta, Canada
Grande Prairie Regional Hospital
Grande Prairie, Alberta, Canada
Grimshaw / Berwyn and District Community Health Centre
Grimshaw, Alberta, Canada
Hanna Health Centre
Hanna, Alberta, Canada
Hardisty Health Centre
Hardisty, Alberta, Canada
Northwest Health Centre
High Level, Alberta, Canada
High Prairie Health Complex
High Prairie, Alberta, Canada
High River General Hospital
High River, Alberta, Canada
Hinton Healthcare Centre
Hinton, Alberta, Canada
Innisfail Health Centre
Innisfail, Alberta, Canada
Seton - Jasper Healthcare Centre
Jasper, Alberta, Canada
Killam Health Centre
Killam, Alberta, Canada
William J Cadzow - Lac La Biche Health Care Centre
Lac La Biche, Alberta, Canada
Lacombe Hospital
Lacombe, Alberta, Canada
Lamont Health Centre
Lamont, Alberta, Canada
Leduc Community Hospital
Leduc, Alberta, Canada
Chinook Regional Hospital
Lethbridge, Alberta, Canada
Lloydminster Hospital
Lloydminster, Alberta, Canada
Manning Community Health Centre
Manning, Alberta, Canada
Mayerthorpe Healthcare Centre
Mayerthorpe, Alberta, Canada
Sacred Heart Community Healt
McLennan, Alberta, Canada
Medicine Hat Regional Hospital
Medicine Hat, Alberta, Canada
Olds Hospital and Care Centre
Olds, Alberta, Canada
Big Country Hospital
Oyen, Alberta, Canada
Peace River Community Health Centre
Peace River, Alberta, Canada
Pincher Creek Health Centre
Pincher Creek, Alberta, Canada
Ponoka Hospital
Ponoka, Alberta, Canada
Provost Health Centre
Provost, Alberta, Canada
Raymond Health Centre
Raymond, Alberta, Canada
Red Deer Regional Hospital Centre
Red Deer, Alberta, Canada
Redwater Health Centre
Redwater, Alberta, Canada
Rimbey Hospital
Rimbey, Alberta, Canada
Rocky Mountain House Health Centre
Rocky Mountain House, Alberta, Canada
Rockyview General Hospital
Rockyview, Alberta, Canada
Slave Lake Healthcare Centre
Slave Lake, Alberta, Canada
George McDougall - Smoky Lake Healthcare Centre
Smoky Lake, Alberta, Canada
Central Peace Health Complex
Spirit River, Alberta, Canada
Sturgeon Community Hospital
St. Albert, Alberta, Canada
St. Therese - St. Paul Healthcare Centre
St. Paul, Alberta, Canada
Stettler Hospital
Stettler, Alberta, Canada
Strathmore District Health Services
Strathmore, Alberta, Canada
Myron Thompson Health Centre
Sundre, Alberta, Canada
Swan Hills Healthcare Centre
Swan Hills, Alberta, Canada
Taber Health Centre
Taber, Alberta, Canada
Three Hills Health Centre
Three Hills, Alberta, Canada
Tofield Health Centre
Tofield, Alberta, Canada
Two Hills Health Centre
Two Hills, Alberta, Canada
Valleyview Health Centre
Valleyview, Alberta, Canada
St. Joseph's General Hospital
Vegreville, Alberta, Canada
Vermilion Health Centre
Vermilion, Alberta, Canada
Viking Health Centre
Viking, Alberta, Canada
Vulcan Community Health Centre
Vulcan, Alberta, Canada
Wabasca/Desmarais Healthcare Centre
Wabasca, Alberta, Canada
Wainwright Health Centre
Wainwright, Alberta, Canada
Westlock Healthcare Centre
Westlock, Alberta, Canada
Westview Health Centre
Westview Village, Alberta, Canada
Wetaskiwin Hospital
Wetaskiwin, Alberta, Canada
Whitecourt Healthcare Centre
Whitecourt, Alberta, Canada
Countries
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Central Contacts
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Facility Contacts
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References
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Remtulla S, Zurek K, Cervera C, Hernandez C, Lee MC, Hoang HL. Impact of an Unsolicited, Standardized Form-Based Antimicrobial Stewardship Intervention to Improve Guideline Adherence in the Management of Staphylococcus aureus Bacteremia. Open Forum Infect Dis. 2019 Feb 26;6(4):ofz098. doi: 10.1093/ofid/ofz098. eCollection 2019 Apr.
Other Identifiers
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Pro00128904
Identifier Type: -
Identifier Source: org_study_id
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