Early Infectious Disease Consultations in Staphylococcus Aureus Bacteremia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-10-31

Study Completion Date

2015-12-31

Brief Summary

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The primary objective is to determine if early infectious disease (ID) consultation (defined as within 48 hours of a positive blood culture) will reduce mortality rates from Staphylococcus aureus bacteremia (SAB). This study will also determine if such consultations could reduce the duration of hospitalisation, recurrence and financial costs in patients with this infection.

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Detailed Description

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Bacteremia is a serious manifestation of Staphylococcus aureus infection with an attributable mortality as high as 25% in MRSA bacteremia. More than a third of patients end up with complications such as endocarditis, osteomyelitis or pneumonia.

Overall the outcome of patients with respect to mortality or recurrence is better in patients who have an eradicable focus and have received an appropriate antibiotic dose and duration. Also complicated bacteremia is more common in patients with

* persistent bacteremia or fever
* prosthetic device
* new murmur
* skin findings of a systemic infection

Based on this evidence, an ID consultation could improve the outcomes of patients with SAB by

* Advising adequate antibiotic dosage and duration
* Sourcing out and counselling eradication of any focus of infection

Conditions

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Staphylococcus Aureus Bacteremia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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ID

Patients receiving an early Infectious disease consultation ( within first 48 hours of a positive blood culture)

Group Type ACTIVE_COMPARATOR

infectious disease specialist consultation

Intervention Type OTHER

Randomised trial to determine the utility of an early Infectious disease Consultation in Staphylococcus aureus bacteremic patients ( in the first 48 hours of a positive blood culture)

NO ID

Includes those patients who do not receive an Infectious disease consultation in the first 48 hours

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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infectious disease specialist consultation

Randomised trial to determine the utility of an early Infectious disease Consultation in Staphylococcus aureus bacteremic patients ( in the first 48 hours of a positive blood culture)

Intervention Type OTHER

Other Intervention Names

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Health Services

Eligibility Criteria

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Inclusion Criteria

* All inpatients at the National University Hospital with Staphylococcus aureus (both methicillin sensitive and methicillin resistant) bacteremia isolated within the defined time period