Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
2000 participants
OBSERVATIONAL
2013-01-31
2016-05-31
Brief Summary
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Detailed Description
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Despite the existence of clinical guidelines, there is considerable variation in the management of S.aureus bacteraemia (SAB) between centres. Part of the variation in clinical management is due to the limited evidence base defining optimal therapy. Fewer than 1500 patients have been recruited to randomised controlled trials in the past 40 years; practice is therefore based largely on experience and observational studies.
The purpose of this evaluation is to record the management and outcome of adults with SAB across multiple European, Asian and North American sites. We aim to establish a broader knowledge base, identify key quality indicators associated with improved outcomes, and to provide comparator data to ensure that patients enrolled in randomized controlled trials are representative of bacteraemic S. aureus patients as a whole. All participating centres are experienced in the management of S. aureus bacteraemia and in conducting evaluations of current management practice and outcomes from S. aureus bacteraemia. Data is checked for plausibility by a centralized data quality control group.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Polymicrobial infection
18 Years
ALL
No
Sponsors
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University of Cologne
OTHER
Responsible Party
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Achim Kaasch
Dr. Achim Kaasch
Principal Investigators
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Achim J Kaasch, MD
Role: STUDY_CHAIR
University of Cologne
Locations
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Uniklinik Koln
Cologne, North Rhine-Westphalia, Germany
Uniklinik Freiburg
Freiburg im Breisgau, , Germany
Univeritatklinikum Schleswig-Holstein
Lübeck, , Germany
Seoul National University Bundang Hospital
Seoul, , South Korea
Hospital San Pau
Barcelona, , Spain
University Hospital Clinic de Barcelona
Barcelona, , Spain
Hospital Vall d'Hebron
Barcelona, , Spain
Hospital Universitario Son Espases
Palma. Mallorca, , Spain
Salamanca Hospital
Salamanca, , Spain
Hospital Universitario Virgen Macarena
Seville, , Spain
Hospital Universitario Virgen del Rocio
Seville, , Spain
Far Eastern Memorial Hospital
New Taipei City, , Taiwan
Birmingham Heartlands Hospital
Birmingham, West Midlands, United Kingdom
Brighton and Sussex University Hospitals
Brighton, , United Kingdom
Cambridge University Hospitals
Cambridge, , United Kingdom
Hull and East Yorkshire Hospitals
Hull, , United Kingdom
Royal Liverpool and Broadgreen Hospital
Liverpool, , United Kingdom
Royal Free Hospital
London, , United Kingdom
Guy's and St Thomas'
London, , United Kingdom
Kings College Hospital
London, , United Kingdom
University College London Hospital
London, , United Kingdom
Oxford University Hospitals
Oxford, , United Kingdom
Plymouth Hospitals
Plymouth, , United Kingdom
Portsmouth Hospitals
Portsmouth, , United Kingdom
Countries
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Central Contacts
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Achim J Kaasch, MD
Role: CONTACT
Christian M Bernasch
Role: CONTACT
Facility Contacts
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Siegbert Rieg, MD
Role: primary
Jan Rupp, MD
Role: primary
Hong Bin Kim
Role: primary
Mercedes Gurgui Ferrer, MD
Role: primary
Alex Soriano, MD
Role: primary
Benito Almirante, MD
Role: primary
Jose Luis Perez Saenz, MD
Role: primary
Hugo Guillermo Ternavasio-de la Vega, MD
Role: primary
Jesus Rodriguez-Bano, MD
Role: primary
Luis Edwardo Lopez-Cortes, MD
Role: primary
Chun-Hsing Liao
Role: primary
Das Pillay, MD
Role: primary
Martin Llewelyn, MD
Role: primary
Estee Torok, MD
Role: primary
Gavin Barlow, MD
Role: primary
Emmanuel Nsutebu, MD
Role: primary
Susan Hopkins, MD
Role: primary
Jonathan Edgeworth, MD
Role: primary
Dakshika Jeyaratnam, MD
Role: primary
Peter Wilson, MD
Role: primary
Matthew Scarborough, MD
Role: primary
Robert Tilley, MD
Role: primary
Sarah Wyllie, MD
Role: primary
References
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Kaasch AJ, Barlow G, Edgeworth JD, Fowler VG Jr, Hellmich M, Hopkins S, Kern WV, Llewelyn MJ, Rieg S, Rodriguez-Bano J, Scarborough M, Seifert H, Soriano A, Tilley R, Torok ME, Weiss V, Wilson AP, Thwaites GE; ISAC, INSTINCT, SABG, UKCIRG, and Colleagues. Staphylococcus aureus bloodstream infection: a pooled analysis of five prospective, observational studies. J Infect. 2014 Mar;68(3):242-51. doi: 10.1016/j.jinf.2013.10.015. Epub 2013 Nov 16.
Other Identifiers
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ISAC-01
Identifier Type: -
Identifier Source: org_study_id