Cohort Study on Plant-based Diets (COPLANT Study)

NCT ID: NCT06323538

Last Updated: 2025-02-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

6000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-04-09

Study Completion Date

2047-03-31

Brief Summary

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The Cohort on Plant-based Diets (COPLANT) study is a multi-centre cohort study that starts baseline recruitment from 2024 to 2027 with approximately 6,000 participants in Germany and Austria. The COPLANT study focuses on vegan (no animal products), vegetarian (no meat and fish, but dairy products and eggs), pescetarian (no meat, but fish) and omnivorous (mixed diet including all possible animal products) diets. The aim of the COPLANT study is to gain new insights on health benefits and risks as well as social, ecological and economic effects of different plant-based diets in comparison to a mixed diet. In addition to a detailed dietary survey using an app adapted to the needs of this study, the baseline examination includes measurements of body composition, bone health, cardiovascular risk factors, diabetes risk, contaminants and lifestyle. For the basic laboratory program, fasting blood, 24-hour urine collection and a stool sample are taken from all study participants. Furthermore, specific aspects of dietary behavior, physical activity and other lifestyle factors are collected via questionnaires. Follow-up studies are planned at intervals of 5, 10 and 20 years after the baseline visit.

Detailed Description

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The multicenter Cohort on Plant-based diets (COPLANT) study, aims to investigate the health benefits as well as short-term and long-term risks of different plant-based diets (vegan: no animal products, vegetarian: no meat and fish, but dairy products and eggs, pescetarian: no meat, but fish) compared to a mixed diet among 6,000 participants aged 18 to 69 years across German speaking countries. Currently the impact of different diets not only on health effects, but also on social, ecological and economic factors is becoming increasingly evident in areas of social justice, climate change and animal welfare. For this reason, a sustainability analysis (social, ecological and economic effects) together with findings on health effects will be included in the COPLANT study. As plant-based diets, especially vegan diets, are associated with specific risks and benefits for certain population groups such as pregnant women, breastfeeding mothers and children, COPLANT will also establish appropriate research structures for these groups and include them in the study.

The detailed consumption survey of all study participants is one of the main pillars of the planned study. Of particular importance is the dietary assessment of novel vegan and vegetarian foods, thus an app adapted to the needs of this study was developed. The characterisation of external and internal intakes of nutrients and contaminants within a particular diet will be examined. Large epidemiological projects currently underway in Germany, such as the NAKO Health Study, are unable to answer these questions. In order to prospectively investigate links between diet and the later occurrence of common diseases such as type 2 diabetes, cardiovascular diseases and cancer, the study participants should be followed up for at least 20 years if third-party funding is successfully acquired.

The study is to be conducted in study centers at the Federal Institute for Risk Assessment (BfR), Berlin, the Max Rubner-Institut (MRI) in Karlsruhe, the Rheinische Friedrich-Wilhelms University in Bonn, the Friedrich Schiller University Jena, the Research Institute for Plant-Based Nutrition in Giessen, in cooperation with the Justus Liebig University Giessen and at the universities of Heidelberg, Regensburg and Vienna. Furthermore, the basic examination includes measurements of body composition, bone health, cardiovascular risk factors, diabetes risk, contaminants and lifestyle. Specific aspects of dietary behavior, physical activity and other lifestyle factors will be assessed using questionnaires. For the basic laboratory program, fasting blood, 24-hour urine collection and a stool sample are taken from all study participants.

Participants will be recruited for the baseline study from 2024 to 2027. Follow-up visits are planned at intervals of 5, 10 and 20 years.

Conditions

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Dietary Exposure Diabetes Mellitus, Type 2 Cardiovascular Diseases Bone Loss Sustainability Exposure Obesity Vitamin Deficiency Mineral Deficiency

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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vegans

vegan diet: no products of animal origin

No interventions assigned to this group

vegetarians

vegetarian diet: no meat and fish, but dairy products and eggs

No interventions assigned to this group

pescetarians

pescetarian diet: no meat, but fish

No interventions assigned to this group

mixed diet

mixed diet: plant-based foods and animal-based foods

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* age between 18 and 69 years at recruitment (age-stratified recruitment in four age groups (18 to 29, 30 to 39, 40 to 49 and 50 to 69 years) which should be equally distributed across the four diets)
* following their current diet for at least one year
* health insured
* are willing to have blood taken (adults)
* are willing and able to complete questionnaires
* only at Berlin, Jena, Giessen and Karlsruhe sites: pregnant and breastfeeding women were recruited (shortened examination programm)
* only at the Regensburg, Heidelberg, Bonn and Vienna sites: are neither pregnant nor breastfeeding at the time of recruitment
* only at Berlin and Karlsruhe sites: children of adult participants (shortened examination programm without collection of blood, urine, and stool)
* are able to give informed consent to participate in the study
* have given their consent to participate in the COPLANT study

Exclusion Criteria

* who can no longer be contacted
* who withdraw their consent to participate in the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

69 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Max Rubner-Institut

UNKNOWN

Sponsor Role collaborator

University of Bonn

OTHER

Sponsor Role collaborator

Research Institute for Plant-Based Nutrition

UNKNOWN

Sponsor Role collaborator

University of Jena

OTHER

Sponsor Role collaborator

University of Regensburg

OTHER

Sponsor Role collaborator

Heidelberg University

OTHER

Sponsor Role collaborator

University of Vienna

OTHER

Sponsor Role collaborator

German Federal Institute for Risk Assessment

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ute Nöthlings, Prof

Role: PRINCIPAL_INVESTIGATOR

University Bonn

Christine Dawczynski, PhD

Role: PRINCIPAL_INVESTIGATOR

University Jena

Markus Keller, PhD

Role: PRINCIPAL_INVESTIGATOR

Research Institute for Plant-based Nutrition (IFPE)

Michael Leitzmann, Prof

Role: PRINCIPAL_INVESTIGATOR

University Regensburg

Ina Danquah, Prof

Role: PRINCIPAL_INVESTIGATOR

University Heidelberg

Maria Wakolbinger, Prof

Role: PRINCIPAL_INVESTIGATOR

University Vienna

Tilman Kühn, Prof

Role: PRINCIPAL_INVESTIGATOR

University Vienna

Beate Fischer, PhD

Role: PRINCIPAL_INVESTIGATOR

University Regensburg

Benedikt Merz, PhD

Role: PRINCIPAL_INVESTIGATOR

Max Rubner-Institut

Cornelia Weikert, Prof

Role: PRINCIPAL_INVESTIGATOR

Federal Institut for Risk Assessment

Locations

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University Vienna

Vienna, , Austria

Site Status RECRUITING

Max Rubner-Institut

Karlsruhe, Baden-Wurttemberg, Germany

Site Status RECRUITING

Friedrich-Schiller University

Jena, Thuringia, Germany

Site Status RECRUITING

The German Federal Institut for Risk Assessment

Berlin, , Germany

Site Status RECRUITING

University Bonn

Bonn, , Germany

Site Status RECRUITING

Research Institute for Plant-Based Nutrition, Gießen

Giessen, , Germany

Site Status NOT_YET_RECRUITING

University Heidelberg

Heidelberg, , Germany

Site Status NOT_YET_RECRUITING

University Regensburg

Regensburg, , Germany

Site Status RECRUITING

Countries

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Austria Germany

Central Contacts

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Cornelia Weikert, Prof

Role: CONTACT

+49 30 184155000

Christine Dawczynski, PhD

Role: CONTACT

+49 3641 949656

Facility Contacts

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Maria Wakolbinger, Prof

Role: primary

Tilman Kühn, Prof

Role: backup

Benedikt Merz, PhD

Role: primary

Christine Dawczynski, PhD

Role: primary

+49 3641 949656

Cornelia Weikert, Prof

Role: primary

+49 30 1841255000

Ute Nöthlings, Prof

Role: primary

Markus Keller, PhD

Role: primary

Ina Danquah

Role: primary

Michael Leitzmann, Prof

Role: primary

Beate Fischer

Role: backup

Provided Documents

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Document Type: Study Protocol

View Document

Related Links

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Other Identifiers

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01

Identifier Type: -

Identifier Source: org_study_id

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