Effect of Intravenous 5% Dextrose Infusion During Recovery from Anesthesia on the Quality of Early Postoperative Recovery in Patients Undergoing Painless Gastrointestinal Endoscopy

NCT ID: NCT06319144

Last Updated: 2025-03-14

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 102 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-03-15
• Study Completion Date: 2024-06-22

Brief Summary

The aim of this study was to determine the effect of intravenous infusion of 5% dextrose injection during the recovery period of anesthesia for painless gastroenteroscopy on the patient's blood glucose level, incidence of hypoglycemia and time of awakening from anesthesia, postoperative vertigo, postoperative nausea and vomiting, and quality of recovery in the early postoperative period.

Conditions

Insulin Resistance; Postoperative Nausea and Vomiting; Quality of Recovery; Dizzyness

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: TRIPLE

Study Groups

Experimental group

Patients in the experimental group were infused intravenously with 5% dextrose (500 ml/h) in the PACU. The study outcomes were collected at three assessment periods, 0-0.5 h, 0.5-6 h, 6-24 h, after anesthesia by an independent investigator.

Group Type: ACTIVE_COMPARATOR

5% glucose

Intervention Type: OTHER

Patients in the experimental group were infused intravenously with 5% dextrose (500 ml/h) in the PACU.

Control group

Patients in the control group were infused intravenously with 0.9% sodium chloride solution (500 ml/h) in the PACU. The study outcomes were collected at three assessment periods, 0-0.5 h, 0.5-6 h, 6-24 h, after anesthesia by an independent investigator.

Group Type: ACTIVE_COMPARATOR

0.9% sodium chloride solution

Intervention Type: OTHER

Patients in the control group were infused intravenously with 0.9% sodium chloride solution in the PACU.

Interventions

5% glucose

Patients in the experimental group were infused intravenously with 5% dextrose (500 ml/h) in the PACU.

Intervention Type: OTHER

0.9% sodium chloride solution

Patients in the control group were infused intravenously with 0.9% sodium chloride solution in the PACU.

Intervention Type: OTHER

Other Intervention Names

5% dextrose; 5% Glucose and sodium chloride injection

Eligibility Criteria

Inclusion Criteria

1. patients who meet the indications for painless gastrointestinal endoscopy and are aged 18 to 79 years.

2. The patient or his/her guardian or immediate family members gave informed consent;

3. American Society of Anesthesiology (ASA) anesthesia risk classification ≤ grade III.

Exclusion Criteria

1. Patients with contraindications to sedation/anesthesia for gastrointestinal endoscopy: e.g., severe hepatic and renal dysfunction, cardiac insufficiency;

2. Patients receiving chemotherapy and opioid treatment; patients with a history of sleep apnea hypoventilation syndrome;

3. Intravenous nutritional support within 8 hours prior to the examination;

4. Patients diagnosed with type I or type II diabetes.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 79 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Weifang Medical University

OTHER

Sponsor Role: lead

Responsible Party

Lin Cheng

Research investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Lin Cheng, B.S

Role: PRINCIPAL_INVESTIGATOR

Weifang People's Hospital

Locations

Lin Cheng

Weifang, Shandong, China

Countries

China

Other Identifiers

KYLL20240306-1

Identifier Type: -

Identifier Source: org_study_id