Perioperative Glucose and Insulin Changes in Major Urologic Surgeries

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-04-15

Study Completion Date

2023-01-05

Brief Summary

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Urological surgery patients will have their blood glucose measured before, during, and after surgery. Blood glucose will be measured using a continuous glucose monitor (CGM) device. We hypothesize the presence of a hyperglycemic state towards the end of surgery due to increased metabolic demand.

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Detailed Description

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Surgical stress causes acute insulin resistance, increased circulating free-fatty acids, and reduced blood glucose uptake resulting in hyperglycemia. Intraoperative and postoperative glucose levels are typically only monitored in the diabetic or cardiac surgical patient. There is a lack of data on perioperative glucose levels in most prolonged surgeries and thus a barrier in determining the best glycemic management strategy to prevent or resolve acute insulin resistance and hyperglycemia. Obtaining blood glucose by CGM is less invasive and will avert disruption of current surgical pathways and standards of care while also producing reliable glucose measurements.

Conditions

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Urologic Diseases Surgery Blood Glucose, High

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Urologic surgery patients

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Adult (≥18 years) undergoing a major urologic surgery (proposed case duration \>4 hours) at The University of Kansas Medical Center (KUMC)
* English speaking

Exclusion Criteria

* Diagnosis of Type 1 or Type 2 diabetes mellitus or an A1C \> 6.5%
* Pregnant or lactating
* Known allergy to milk, soy, egg, wheat, peanuts, or tree nuts
* Swallowing difficulties

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No