Blood/Interstitial Glucose Measurements and Cognitive Function During Hypoglycemia and Recovery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2015-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to find out the effects of hypoglycemia on cognition in healthy individuals and how well changes in (interstitial) tissue glucose levels correlate with changes in cognitive function as compared to blood glucose levels.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Cognition in Patients With Hypoglycemia, Without Diabetes

NCT04430582

Hypoglycemia Cognition

COMPLETED

Identifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 Diabetes

NCT02866435

Hypoglycemia

COMPLETED EARLY_PHASE1

Microdialysis and Jugular Bulb Glucose Profiles During Hyperglycaemic Clamping in Patients with Severe Acute Brain Injury

NCT06393049

Acute Brain Injury

RECRUITING NA

Cerebral Responses to Insulin Induced Hypoglycemia

NCT02747680

Type 1 Diabetes Healthy Hypoglycemia Unawareness

COMPLETED NA

Blood Glucose Control in Intensive Care Patients Using the Space GlucoseControl System

NCT01523665

Intensive Care Patients

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Subjects will undergo hypoglycemic clamps during which interstitial glucose will be measured and cognitive function will be assessed.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Hypoglycemia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Euglycemic and hypoglycemic clamp

Subjects will complete clamp study visit.

Group Type EXPERIMENTAL

euglycemic and hypoglycemic clamp

Intervention Type PROCEDURE

Subjects will undergo standard euglycemic and hypoglycemic clamps, and will have concurrent assessments of cognitive function and measurement of interstitial glucose concentrations.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

euglycemic and hypoglycemic clamp

Subjects will undergo standard euglycemic and hypoglycemic clamps, and will have concurrent assessments of cognitive function and measurement of interstitial glucose concentrations.

Intervention Type PROCEDURE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

clamp

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* non obese (BMI \<30), ages 18-50

Exclusion Criteria

* renal or hepatic failure
* cancer or lymphoma
* malabsorption or malnourishment
* hypercortisolism
* alcoholism or drug abuse
* anemia
* eating disorder or depression
* coronary artery disease
* Arrhythmias
* hypertension
* on medications known to affect the blood glucose to be measured such as
* glucocorticoids
* on blood thinning agents

* Pregnant women, breastfeeding women and women who want to become pregnant in the next 6 months will be excluded from the study.
* Subjects who have donated blood two weeks prior to the study.
* Allergies to pig derived products (Heparin will be used)

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes