Perioperative Factors and Living Donor Liver Transplantation

NCT ID: NCT06312098

Last Updated: 2024-03-18

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 533 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-04-01
• Study Completion Date: 2024-07-01

Brief Summary

Liver transplant surgery is one of the treatments provided to patients suffering from end-stage liver disease, and has a successful treatment prognosis. However, it is clear that patient management before, during, and after surgery is a difficult task for medical staff due to the complex clinical and pathological problems of end-stage liver disease. Moreover, the complex surgical technique of the liver transplant surgery itself and the severe hemodynamic fluctuations and multi-organ dysfunction that patients experience during the surgery have been shown to have a tremendous impact on the patient's prognosis after surgery.

A study on which clinical, laboratory, and hemodynamic factors experienced by patients during the perioperative period, including before, during, and after surgery, affect the survival rate of patients and transplanted organs. will definitely be helpful in the treatment of patients suffering from end-stage liver disease.

Conditions

Liver Transplant Disorder

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

no-remote ischemic preconditioning group

patients who did not receive remote ischemic preconditioning

No interventions assigned to this group

paired remote ischemic preconditioning group

patients who receive remote ischemic preconditioning

remote ischemic preconditioning (RIPC)

Intervention Type: OTHER

After induction of anesthesia, the paired RIPC group took the RIPC intervention on the upper arm in the lateral position. The RIPC intervention was applied using a manual cuff inflator, which consisted of three cycles of 5-min inflation of the blood pressure cuff (to 250 mmHg, or to 50 mmHg higher than the preoperative SBP), followed by 5-min deflation of the cuff. In the no-RIPC group, a blood pressure cuff was also applied on the upper arm but was not inflated.

Interventions

remote ischemic preconditioning (RIPC)

After induction of anesthesia, the paired RIPC group took the RIPC intervention on the upper arm in the lateral position. The RIPC intervention was applied using a manual cuff inflator, which consisted of three cycles of 5-min inflation of the blood pressure cuff (to 250 mmHg, or to 50 mmHg higher than the preoperative SBP), followed by 5-min deflation of the cuff. In the no-RIPC group, a blood pressure cuff was also applied on the upper arm but was not inflated.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• adults
• elective surgery
• American Society of Anesthesiologists (ASA) physical status classification system I, II, III

Exclusion Criteria

• American Society of Anesthesiologists (ASA) physical status classification system IV, V

• Minimum Eligible Age: 19 Years
• Maximum Eligible Age: 79 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Min Suk Chae

OTHER

Sponsor Role: lead

Responsible Party

Min Suk Chae

professor

Responsibility Role: SPONSOR_INVESTIGATOR

Other Identifiers

KC21RISI0576

Identifier Type: -

Identifier Source: org_study_id