High Versus Low Blood-Pressure Target in the Post Operative Care of Liver Transplantation A Randomized, Controled, Open and Unicentric Trial.
NCT ID: NCT05068713
Last Updated: 2024-01-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
174 participants
INTERVENTIONAL
2021-08-24
2024-01-05
Brief Summary
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A randomized, controled, open and unicentric trial comparing high (MAP 85-90 mmHg) and low (65-70 mmHg) target of mean arterial pressure in the first 24 hours after liver transplantation.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Hihg Target Mean Arterial Pressure
Target of mean arterial pressure of 85-90 mmHg in ther first 24h after liver transplant.
Usual Care + High Target of Mean Arterial Pressure
Targeting the weaning of vasopressors to a mean arterial pressure of 85-90mmHg in the first 24h after liver trasnplant.
Low Target Mean Arterial Pressure
Target of mean arterial pressure of 65-70 mmHg in ther first 24h after liver transplant.
Usual Care
Targeting the weaning of vasopressors to a mean arterial pressure of 65-70mmHg in the first 24h after liver trasnplant.
Interventions
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Usual Care + High Target of Mean Arterial Pressure
Targeting the weaning of vasopressors to a mean arterial pressure of 85-90mmHg in the first 24h after liver trasnplant.
Usual Care
Targeting the weaning of vasopressors to a mean arterial pressure of 65-70mmHg in the first 24h after liver trasnplant.
Eligibility Criteria
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Inclusion Criteria
* Admitted in the ICU for a post operative care after liver transplant
Exclusion Criteria
* Liver transplant due to acute liver failure
* Renal transplant ( Previous or concomitant)
* Refusal from the healthcare provider responsible for the patient
* Renal substitution therapy in the prior 15 days
* Pregnancy
* Re-Transplant (Liver transplant in the previous 6 month)
* Hepatorenal syndrome current treatment (Use of terlipressin + Albumin)
* Refractory and persistent shock during or after transplant
18 Years
ALL
No
Sponsors
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University of Sao Paulo General Hospital
OTHER
Responsible Party
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Rodolpho Augusto de Moura Pedro
Principal investigator
Locations
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Hospital Das Clínicas Da Faculdade de Medicina Da Universidade de São Paulo
São Paulo, São Paulo, Brazil
Countries
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References
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Pedro RAM, Scharranch BC, Araujo LO, Brandao LS, Andrade LDC, Andraus W, D'Albuquerque LAC, Malbouisson LMS. High versus low mean arterial pressure target in liver transplant patients. An open, controlled, single-center, randomized clinical trial - Protocol and methods (LIVER-PAM). Crit Care Sci. 2023 Mar 1;35(1):11-18. doi: 10.5935/2965-2774.20230336-en.
Other Identifiers
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LIVER-PAM
Identifier Type: -
Identifier Source: org_study_id
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