Early Extubation and Postoperative Complications After Liver Transplantation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

438 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-15

Study Completion Date

2020-04-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is a retrospective cohort study. Patients who underwent liver transplantation from January 1, 2016 to December 31, 2019 were admitted to the study and divided into two groups. Operating room extubation group: early extubation in the operating room immediately following liver transplantation. Intensive care unit (ICU) extubation group: delay extubation in the ICU following liver transplantation. The primary objectives were to compare the incidence of composite outcome between the two groups. secondary objectives were to compare outcomes such as length of stay, hospital length of stay, and total cost between the two groups.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

End-of-Life Decisions in Surgical Intensive Care Medicine - The Relevance of Treatment Withholding

NCT02521428

Quality of Life

COMPLETED

The Correlation Between Cirrhotic Cardiomyopathy and Perioperative Cardiovascular Events in Liver Transplantation

NCT04976764

Cirrhosis, Liver

UNKNOWN

Predictive Factors for Massive Transfusion During Liver Transplantation

NCT05763446

Liver Transplant; Complications

RECRUITING

Hepatic Hemodynamic Changes and Simulation in Living-Related Liver Transplantation

NCT00234624

Right Hepatectomy

UNKNOWN

Fluid Management Strategies on Blood Loss in Liver Transplantation

NCT06215404

Liver Transplant

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Patients who underwent liver transplantation from January 1, 2016 to December 31, 2019 were admitted to the study. Inclusion criteria: (1) adult patients (age ≥ 18 years), (2) undergoing liver transplantation. Exclusion criteria were the following: (1) re-transplantation; (2) multi-visceral transplantation; (3) intraoperative death; (4) severe encephalopathy (West Haven criteria III or IV); (5) those who had preoperative mechanical ventilation; (6) incomplete clinical data. The primary objectives was a composite of 30-day all-cause mortality, in-hospital AKI, or in-hospital moderate to severe pulmonary complications. Complications were defined and graded as mild, moderate, or severe as described by European Perioperative Clinical Outcome definitions and were included if they occurred in hospital after surgery. The secondary objectives included in-hospital moderate to severe infectious complications, unplanned reintubation rates, ICU and postoperative hospital lengths of stay, and total hospital cost.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Liver Transplantation

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Operating room extubation group

extubation in the operating room immediately following liver transplantation

extubation in the operating room

Intervention Type PROCEDURE

Patients who underwent liver transplantation early extubation in the operating room immediately following liver transplantation

ICU extubation group

extubation in the ICU following liver transplantation

extubation in the ICU

Intervention Type PROCEDURE

Patients who underwent liver transplantation extubation in the ICU following liver transplantation

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

extubation in the operating room

Patients who underwent liver transplantation early extubation in the operating room immediately following liver transplantation

Intervention Type PROCEDURE

extubation in the ICU

Patients who underwent liver transplantation extubation in the ICU following liver transplantation

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adult patients (age ≥ 18 years)
* Undergoing liver transplantation

Exclusion Criteria

* Re-transplantation
* Multi-organ transplants
* Intra-operative deaths
* severe encephalopathy (West Haven criteria III or IV)
* patients who had preoperative mechanical ventilation or fulminant hepatic failure
* Incomplete clinical data

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No