Auditory Sensory Attenuation in Anorexia Nervosa

NCT ID: NCT06298526

Last Updated: 2025-09-08

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 31 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-03-01
• Study Completion Date: 2025-06-30

Brief Summary

The goal of this observational cross-sectional study is to test the sensory attenuation effect with auditory stimuli comparing women affected by anorexia nervosa and healthy-weight women. Specifically, the study aims to test whether the sensory attenuation effect (i.e., the perceived loudness of a self-generated sound is weaker than when another person produces the same sound):

i) is observed in anorexia nervosa ii) it can be modulated in interactive action contexts, as was previously observed in healthy participants.

Participants will compare the loudness of target sound with a comparison tone, which can be prompt by the participant by pressing a button on their own will (i.e., individual context) or upon the experimenter's signal (i.e., interactive context); externally-generated sounds are produced in the opposite way.

Detailed Description

The perceived loudness of a self-generated sound is generally weaker than when another person produces the same sound. This effect is known as sensory attenuation, and it is considered a proof of sense of agency (i.e., it relies on the anticipation of the sensory-motor effects of one's intentional action). Recently, it was suggested that this effect is enhanced in interactive action contexts in healthy individuals, meaning that sounds are produced as a consequence of cooperation between individuals.

Participants will compare the loudness of target sound with a comparison tone, which could be generated in 4 different conditions:

i) participants press a button ii) the experimenter press the button iii) participants press the button upon the experimenter's signal (i.e., who touch the participants' arm) iv) the experimenter presses the button upon the participants' signal (i.e., who touch the experimenter's arm).

However, it is not clear whether the same effect of cooperation can be observed also when individuals experience difficulties in social interactions and relationships.

To this purpose, the study compared the sensory attenuation effect for auditory stimuli in a traditional (i.e., individual) and interactive context, comparing women affected by anorexia nervosa with healthy-weight women.

Indeed, relational difficulties and social withdrawal characterized this clinical condition.

Conditions

Anorexia Nervosa

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

women with anorexia nervosa

DSM-V criteria for anorexia nervosa must be satisfied

No interventions assigned to this group

healthy weight women

BMI range: 19-29 kg/m2

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• diagnosis of anorexia nervosa according to the DSM-V classification (experimental group)
• BMI ranged between 19 - 25 kg/m2 (controls)
• handedness: right

Exclusion Criteria

• history of eating disorders (controls)
• major psychiatric conditions (e.g., psychosis, personality disorders)
• developmental disorders (e.g., autism spectrum disorders)
• neurological or brain injuries disorders
• motor impairments

• Minimum Eligible Age: 18 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Istituto Auxologico Italiano

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

IRCCS Istituto Auxologico Italiano, San Giuseppe Hospital

Piancavallo, VCO, Italy

Countries

Italy

References

Colle L, Hilviu D, Boggio M, Toso A, Longo P, Abbate-Daga G, Garbarini F, Fossataro C. Abnormal sense of agency in eating disorders. Sci Rep. 2023 Aug 30;13(1):14176. doi: 10.1038/s41598-023-41345-5.

Reference Type: BACKGROUND

PMID: 37648816 (View on PubMed)

Weiss C, Herwig A, Schutz-Bosbach S. The self in social interactions: sensory attenuation of auditory action effects is stronger in interactions with others. PLoS One. 2011;6(7):e22723. doi: 10.1371/journal.pone.0022723. Epub 2011 Jul 27.

Reference Type: BACKGROUND

PMID: 21818373 (View on PubMed)

Other Identifiers

21C307

Identifier Type: -

Identifier Source: org_study_id