Ovulation Triggering 2 vs 3 Follicles

NCT ID: NCT06290921

Last Updated: 2025-03-20

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 405 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-02-22
• Study Completion Date: 2024-06-11

Brief Summary

Poor responders in in-vitro fertilization (IVF) cycles represent a major challenge for fertility specialists. Although poor responders tend to have sub-optimal fertility treatment outcomes, many of these patients wish to attempt at least one IVF cycle. Traditionally, IVF cycles producing less than 3 to 4 mature follicles (measuring at least 14 mm) have either been cancelled or converted to intra-uterine insemination (IUI) due to the low pregnancy rates associated with these cycles. The minimal number of follicles required to proceed with egg collection is based on clinical experience, having been determined by weighing the probability of implantation and pregnancy versus the risk of not obtaining quality oocytes or reaching embryo transfer when fewer mature follicles are present. This retrospective quality control study aims to compare pregnancy rates in IVF cycles producing 3 follicles measuring 14 mm and more on trigger day, versus 2 or fewer follicles.

Conditions

Infertility

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Interventions

Ovulation triggering

Ovulation triggering when women only 2 dominant follicles as opposed to the clinic's standard of 3 follicles or more

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Stimulated IVF cycle at clinique ovo
• Patients with a maximum of 3 mature follicles (≥14mm) on the day of ovulation trigger

Exclusion Criteria

• Cycle cancelation due to no follicles
• History of recurrent implantation failure
• Contraindication of ovulation induction medication

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 42 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Clinique Ovo

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Louise Lapensée, MD

Role: PRINCIPAL_INVESTIGATOR

Clinique Ovo

Locations

Clinique Ovo

Montreal, Quebec, Canada

Countries

Canada

Other Identifiers

3472

Identifier Type: -

Identifier Source: org_study_id