Assessment of Patient-ventilator Asynchrony by Electric Impedance Tomography

NCT ID: NCT06290310

Last Updated: 2024-03-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-04-12

Study Completion Date

2024-09-01

Brief Summary

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Patient-ventilator asynchrony (PVA) has deleterious effects on the lungs. PVA can lead to acute lung injury and worsening hypoxemia through biotrauma. Little is known about how PVA affects lung aeration estimated by electric impedance tomography (EIT). Artificial intelligence can promote the detection of PVA and with its help, EIT measurements can be correlated to asynchrony.

Detailed Description

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Patient-ventilator asynchrony (PVA) is a common phenomenon with invasively- and non-invasively ventilated patients. PVA has deleterious effects on the lungs. It causes not just patient discomfort and distress but also leads to acute lung injury and worsening hypoxemia through biotrauma. The latter significantly impacts outcomes and increases the duration of mechanical ventilation and intensive care unit stay.

However, PVA is a widely investigated incident related to mechanical ventilation, though little is known about how it affects lung aeration estimated by electric impedance tomography (EIT). EIT is a non-invasive, real-time monitoring technique suitable for detecting changes in lung volumes during ventilation.

Artificial intelligence can promote the detection of PVA by flow versus time assessment. If continuous EIT recording is correlated with the latter, impedance tomography changes evoked by asynchrony can be estimated

Conditions

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Acute Lung Injury

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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mechanically ventilated patients

Invasively or non-invasively ventilated patients.

EIT

Intervention Type DEVICE

continuous electric impedance tomography measurement

patient-ventilator asynchrony assessment

Intervention Type DEVICE

patient-ventilator asynchrony assessment by flow/time curve and machine learning

Interventions

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EIT

continuous electric impedance tomography measurement

Intervention Type DEVICE

patient-ventilator asynchrony assessment

patient-ventilator asynchrony assessment by flow/time curve and machine learning

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* any patient ventilated invasively
* any patient ventilated non-invasively

Exclusion Criteria

* age under 18
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hochschule Furtwangen University

OTHER

Sponsor Role collaborator

Budapest University of Technology and Economics

OTHER

Sponsor Role collaborator

Szeged University

OTHER

Sponsor Role collaborator

Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Kiskunhalas Semmelweis Hopsital the Teaching Hospital of the University of Szeged

Kiskunhalas, , Hungary

Site Status

Countries

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Hungary

Central Contacts

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András Lovas, M.D. Ph.D.

Role: CONTACT

003677522000 ext. 2045

Facility Contacts

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András Lovas, M.D. Ph.D.

Role: primary

003677522000 ext. 2045

References

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Sottile PD, Albers D, Smith BJ, Moss MM. Ventilator dyssynchrony - Detection, pathophysiology, and clinical relevance: A Narrative review. Ann Thorac Med. 2020 Oct-Dec;15(4):190-198. doi: 10.4103/atm.ATM_63_20. Epub 2020 Oct 10.

Reference Type RESULT
PMID: 33381233 (View on PubMed)

Bachmann MC, Morais C, Bugedo G, Bruhn A, Morales A, Borges JB, Costa E, Retamal J. Electrical impedance tomography in acute respiratory distress syndrome. Crit Care. 2018 Oct 25;22(1):263. doi: 10.1186/s13054-018-2195-6.

Reference Type RESULT
PMID: 30360753 (View on PubMed)

Other Identifiers

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PAVELA

Identifier Type: -

Identifier Source: org_study_id

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