Photon Counting Detector CT Image Quality

NCT ID: NCT06281808

Last Updated: 2025-10-02

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 200 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-01-28
• Study Completion Date: 2026-12-31

Brief Summary

This study aims to compare subjective image quality and diagnostic accuracy of a photon counting detector computed tomography (PCD-CT) scanner compared with an energy integrating detector (EID)-CT scanner as the reference standard.

Detailed Description

Computed tomography (CT) imaging plays a key role in diagnostic radiology, and is particularly valuable in assessing a myriad of musculoskeletal conditions (e.g. trauma, degenerative disorders, post-surgical follow-up, inflammatory diseases).

The vast majority of today's CT scanners are equipped with an energy-integrating detector (EID), which converts energy of incoming X-ray photons in a two-step process into electric signals: First, scintillators generate visible light, which in turn is converted to the electric signal by photodiodes.

Recently, photon-counting detector computed tomography (PCD-CT) scanners became commercially available and have been introduced to improve imaging performance through direct transformation of X-ray photons into electron hole pairs upon absorption in a semiconductor layer, generating an electrical signal proportional to the photon energy.

Current literature has shown that PCD-CT can offer higher spatial resolution, increased contrast-to-noise ratio, higher dose-efficiency, and inherent multi-spectral imaging capacity.

Moreover, the results from cadaver studies suggest that PCD-CT can preserve image quality with reduced radiation dose.

However, data on the diagnostic accuracy of PCD-CT compared to EID-CT is currently limited in the field of musculoskeletal radiology.

In addition to conventional CT acquisition, multi-spectral CT imaging in patients with gout and after trauma, is used in clinical routine to delineate materials with a specific absorption coefficient: in gout, urate crystals can be visualized, while after trauma, bone marrow edema can be detected. For EID-CT, different techniques for multi-spectral CT imaging are available (e.g. fast kV switching, dual source CT) which are widely used in clinical routine. Multi-spectral imaging is also inherently available for recently introduced PCD-CT. However, data on diagnostic accuracy of multi-spectral PCD-CT is currently lacking.

Conditions

Diagnostic Imaging; Tomography, X Ray Computed

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

Photon Counting Detector CT

PCD CT

Group Type: EXPERIMENTAL

Photon Counting Detector CT

Intervention Type: DEVICE

Photon counting detector CT scan with dose arbitrarily reduced compared to EID CT scan (e.g., half the dose of EID CT)

Interventions

Photon Counting Detector CT

Photon counting detector CT scan with dose arbitrarily reduced compared to EID CT scan (e.g., half the dose of EID CT)

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Patient admitted for non-contrast enhanced CT scan of the upper or lower extremity at the radiology department of Balgrist University Hospital
• Signed general consent ("Information zur Weiterverwendung gesundheitsbezogener Daten und Proben zu Forschungszwecken")
• >18 years of age
• Written consent to participate in this study

Exclusion Criteria

• Clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.)
• Women: pregnancy
• Age below 18 years
• Known or suspected non-compliance, drug or alcohol abuse
• Inability to consent and/or follow the procedures of the investigation, e.g. due to language problems, psychological disorders, dementia, etc. of the subject
• Enrolment of the PI, his/her family members, employees and other dependent persons
• Body mass above 200 kg.
• Body mass below 31 kg.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Reto Sutter, MD

OTHER

Sponsor Role: lead

Responsible Party

Reto Sutter, MD

Prof. Dr. med. Reto Sutter

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Balgrist University Hospital

Zurich, Canton of Zurich, Switzerland

Countries

Switzerland

Other Identifiers

R490

Identifier Type: -

Identifier Source: org_study_id