Beverage Hydration Index: Assessment of Four Rehydration Solutions

NCT ID: NCT06272435

Last Updated: 2024-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-23

Study Completion Date

2024-09-06

Brief Summary

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No studies to date to evaluate the effects of the three different liquid IV electrolyte products on the beverage hydration index (BHI). Therefore, the purpose of this study is to determine the impact of three different LIV products (Hydration multiplier, Sugar Free formulation with Amino Acids, and Sugar Free with allulose) on hydration status in young and active men and women compared to a control (water). The study will follow the same approach as used by Maughan and colleagues (2016) to measure the fluid balance (the difference between the amount of water consumed and passed as urine) and BHI (the relative amount of urine passed after consumption of a drink compared to water) including time in positive fluid balance, as well as determining electrolyte concentrations, osmolality, specific gravity, and sodium and potassium in urine.

Detailed Description

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Many attempts have been made to improve and measure the hydration status of active individuals. This typically involves the ingestion of fluids leading up to activity (typically plain water), as well as the ingestion of fluids during the activity itself (water, along with a diluted carbohydrate/electrolyte beverage). This approach seems to work well; however, some debate remains over what the best fluid is to consume, in particular related to the macronutrient type and the specific electrolyte mix.

No studies to date to evaluate the effects of the three different liquid IV electrolyte products on the beverage hydration index (BHI). Therefore, the purpose of this study is to determine the impact of three different LIV products (Hydration multiplier, Sugar Free formulation with Amino Acids, and Sugar Free with allulose) on hydration status in young and active men and women compared to a control (water). The study will follow the same approach as used by Maughan and colleagues (2016) to measure the fluid balance (the difference between the amount of water consumed and passed as urine) and BHI (the relative amount of urine passed after consumption of a drink compared to water) including time in positive fluid balance, as well as determining electrolyte concentrations, osmolality, specific gravity, and sodium and potassium in urine.

Conditions

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Hydration

Keywords

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Liquid IV Electrolyte Beverage Hydration Index

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Semi-blinded, placebo controlled, crossover design
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants
Treatments will be labeled A-D. Subjects will be provided prepared beverages prepared in cup.

Study Groups

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Water, Multiplier, Sugar with Amino Acids, and Sugar Free

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Water, Multiplier, Sugar Free, and Sugar with Amino Acids

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Water, Sugar with Amino Acids, Multiplier, and Sugar Free

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Water, Sugar with Amino Acids, Sugar Free, and Multiplier

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Water, Sugar Free, Multiplier, and Sugar with Amino Acids

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Water, Sugar Free, Sugar with Amino Acids, and Multiplier

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Multiplier, Water, Sugar with Amino Acids, and Sugar Free

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Multiplier, Water, Sugar Free, and Sugar with Amino Acids

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Multiplier, Sugar with Amino Acids, Water, and Sugar Free

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Multiplier, Sugar with Amino Acids, Sugar Free, and Water

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Multiplier, Sugar Free, Water, and Sugar with Amino Acids

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Multiplier, Sugar Free, Sugar with Amino Acids, and Water

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Sugar with Amino Acids, Water, Multiplier, and Sugar Free

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Sugar with Amino Acids, Water, Sugar Free, and Multiplier

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Sugar with Amino Acids, Multiplier, Water, and Sugar Free

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Sugar with Amino Acids, Multiplier, Sugar Free, and Water

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Sugar with Amino Acids, Sugar Free, Water, and Multiplier

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Sugar with Amino Acids, Sugar Free, Multiplier, and Water

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Sugar Free, Water, Multiplier, and Sugar with Amino Acids

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Sugar Free, Water, Sugar with Amino Acids, and Multiplier

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Sugar Free, Multiplier, Water, and Sugar with Amino Acids

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Sugar Free, Multiplier, Sugar with Amino Acids, and Water

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Sugar Free, Sugar with Amino Acids, Water, and Multiplier

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Sugar Free, Sugar with Amino Acids, Multiplier, and Water

Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected.

Group Type EXPERIMENTAL

Multiplier

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Sugar Free with Amino Acids

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Water

Intervention Type DIETARY_SUPPLEMENT

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Multiplier

Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Intervention Type DIETARY_SUPPLEMENT

Sugar Free

Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.

Intervention Type DIETARY_SUPPLEMENT

Sugar Free with Amino Acids

Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.

Intervention Type DIETARY_SUPPLEMENT

Water

Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* body mass index (BMI) \<35 kilgrams per square meter
* consistent dietary intake and exercise throughout study period
* consumes 2 liters (women) or 2.5 liters (men) of water per day prior to study visits
* able to fast for 15 hours

Exclusion Criteria

* sensitivity or be allergic to any components of the study product they will be excluded.
* tobacco user
* specialized diet (low carbohydrate/ketogenic diet, carnivore diet, intermittent fasting, etc.)
* caffeine consumption within 12 hours of study visit
* strenuous activity within 24 hours of study visit
* history or presence of a clinically relevant (that required or requires treatment) cardiac, renal, hepatic, endocrine (including diabetes mellitus), pulmonary, biliary, gastrointestinal, pancreatic, or neurologic disorder
* conditions that alter fluid balance or electrolytes/hydration status
* consuming any medication which may alter fluid retention/electrolyte levels such as sodium-glucose co-transporter 2 (SGLT2) inhibitor (for type 2 diabetes), laxatives, diuretics, Apremilast, chemotherapy, or lithium.
* consuming nutritional supplements, performance enhancing drugs, and/or non-steroidal anti-inflammatory drugs within 7 days of study visits excluding screening).
* employee of Liquid IV
* be enrolled in another clinical study within 30 days of the first study visit
* active infection or illness of any kind
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Memphis

OTHER

Sponsor Role lead

Responsible Party

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Richard Bloomer

Dean of College of Health Sciences

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Richard Bloomer, PhD

Role: PRINCIPAL_INVESTIGATOR

Center for Nutraceutical and Dietary Supplement Research

Locations

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Center for Nutraceutical and Dietary Supplement Research

Memphis, Tennessee, United States

Site Status

Countries

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United States

Other Identifiers

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PRO-FY2024-64

Identifier Type: -

Identifier Source: org_study_id