Effect of Metabolic Dysfunction in Branched-chain Amino Acids on Cardiac Function in Patients With Sepsis

NCT ID: NCT06258252

Last Updated: 2024-06-14

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 50 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-06-15
• Study Completion Date: 2026-03-15

Brief Summary

The current project was designed to examine the effects of BCAA metabolic dysfunction on cardiac function in septic patients.

Detailed Description

Patients with sepsis and with/without type 2 diabetes will be included. Patients prospectively collected the following indicators in the intensive care unit: 1. myocardial injury-related biomarkers: troponin T and B natriuretic peptide levels; 2. cardiac structure-related indicators: the size of the left and right ventricle, left ventricular ejection fraction, etc.3. septic cardiomyopathy incidence: Troponin T>0.01ng/ml is the standard for the diagnosis of septic cardiomyopathy. Additionally, the investigators will collect the peripheral blood at preoperative, day 1, day 3, and day 5 after surgery. Peripheral blood plasma and PBMCs were separated by differential centrifugation: the concentration of BCAAs in serum and PBMCs; the expression of PBMCs BCAAs metabolic enzymes BCAT 1, BCKDH, and PP 2 Cm by WB; and the levels of AST, ALT, LDH, CK, and CK-MB

Conditions

Sepsis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Patients who are diagnosed as sepsis, with type 2 diabetes.

1\. myocardial injury-related biomarkers: troponin T and B natriuretic peptide levels; 2. cardiac structure-related indicators: the size of the left and right ventricle, left ventricular ejection fraction, etc.3. septic cardiomyopathy incidence: Troponin T\>0.01ng/ml is the standard for the diagnosis of septic cardiomyopathy.

Effect of BCAAs metabolic dysfunction on cardiac function in sepsis

Intervention Type: OTHER

Effect of BCAAs metabolic dysfunction on cardiac function in sepsis

Patients who are diagnosed as sepsis, without type 2 diabetes.

1\. myocardial injury-related biomarkers: troponin T and B natriuretic peptide levels; 2. cardiac structure-related indicators: the size of the left and right ventricle, left ventricular ejection fraction, etc.3. septic cardiomyopathy incidence: Troponin T\>0.01ng/ml is the standard for the diagnosis of septic cardiomyopathy.

Effect of BCAAs metabolic dysfunction on cardiac function in sepsis

Intervention Type: OTHER

Effect of BCAAs metabolic dysfunction on cardiac function in sepsis

Interventions

Effect of BCAAs metabolic dysfunction on cardiac function in sepsis

Effect of BCAAs metabolic dysfunction on cardiac function in sepsis

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• patients diagnosed with sepsis with or without type 2 diabetes

Exclusion Criteria

• patients with immunodeficient diseases patients who accept glucocorticoid or immunosuppressant patients with an age younger than 18 years patients who cannot provide informed consent

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

West China Hospital

OTHER

Sponsor Role: lead

Responsible Party

Chunling Jiang

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Fengmin Luo, PhD

Role: PRINCIPAL_INVESTIGATOR

West China Hospital

Central Contacts

Chunling Jiang, PhD

Role: CONTACT

jiangchunling@scu.edu.cn

18980601096

Other Identifiers

20240201

Identifier Type: -

Identifier Source: org_study_id