Predictors of Mortality Among Ventilator Associated Pneumonia Patients

NCT ID: NCT06246994

Last Updated: 2024-02-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

140 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-03-31

Study Completion Date

2025-09-30

Brief Summary

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In this context, this study aims to explore the risk factors for mortality from VAP in respiratory ICU.

Detailed Description

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Pneumonia is the most common infection treated within ICUs and carries significant mortality risk . Ventilator-associated pneumonia (VAP) is a specific form of nosocomial pneumonia occurring in patients greater than 48 hours after intubation and the initiation of mechanical ventilation .

VAP is considered a leading cause of morbidity and mortality among intensive care unit infections. Despite various preventive measures, the incidence of VAP remains high .

In studies, VAP-related mortality is 14-70% . It is contemplated that there are independent risk factors, increasing VAP-related mortality .

However, the question of which factors are associated with early or late mortality in patients with VAP diagnosis, remains unanswered. Early identification and understanding of the etiology of VAP in the ICU is essential to prevent mortality and morbidity.

Conditions

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Pneumonia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. adult participants over 18 years old who had undergone mechanical ventilation for longer than 48 hours.
2. Only the first episode of VAP for each patient will be included.

Exclusion Criteria

1. Patients who are less than 18 years old.
2. Pneumonia diagnosed before mechanical ventilation.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Marwa Hussien kilany

principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Doaa Magdy, assisst -professor

Role: STUDY_DIRECTOR

Assiut University

Central Contacts

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Marwa Kilany, Assisst- lecture

Role: CONTACT

01064123545

Saher Mahmoud, lecture

Role: CONTACT

01002866364

References

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Vincent JL, Sakr Y, Singer M, Martin-Loeches I, Machado FR, Marshall JC, Finfer S, Pelosi P, Brazzi L, Aditianingsih D, Timsit JF, Du B, Wittebole X, Maca J, Kannan S, Gorordo-Delsol LA, De Waele JJ, Mehta Y, Bonten MJM, Khanna AK, Kollef M, Human M, Angus DC; EPIC III Investigators. Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017. JAMA. 2020 Apr 21;323(15):1478-1487. doi: 10.1001/jama.2020.2717.

Reference Type RESULT
PMID: 32207816 (View on PubMed)

Zhou XY, Ben SQ, Chen HL, Ni SS. A comparison of APACHE II and CPIS scores for the prediction of 30-day mortality in patients with ventilator-associated pneumonia. Int J Infect Dis. 2015 Jan;30:144-7. doi: 10.1016/j.ijid.2014.11.005. Epub 2014 Nov 12.

Reference Type RESULT
PMID: 25461659 (View on PubMed)

Arayasukawat P, So-Ngern A, Reechaipichitkul W, Chumpangern W, Arunsurat I, Ratanawatkul P, Chuennok W. Microorganisms and clinical outcomes of early- and late-onset ventilator-associated pneumonia at Srinagarind Hospital, a tertiary center in Northeastern Thailand. BMC Pulm Med. 2021 Jan 30;21(1):47. doi: 10.1186/s12890-021-01415-8.

Reference Type RESULT
PMID: 33516213 (View on PubMed)

John AO, Paul H, Vijayakumar S, Anandan S, Sudarsan T, Abraham OC, Balaji V. Mortality from acinetobacter infections as compared to other infections among critically ill patients in South India: A prospective cohort study. Indian J Med Microbiol. 2020 Jan-Mar;38(1):24-31. doi: 10.4103/ijmm.IJMM_19_492.

Reference Type RESULT
PMID: 32719205 (View on PubMed)

Zimmerman JE, Kramer AA, McNair DS, Malila FM, Shaffer VL. Intensive care unit length of stay: Benchmarking based on Acute Physiology and Chronic Health Evaluation (APACHE) IV. Crit Care Med. 2006 Oct;34(10):2517-29. doi: 10.1097/01.CCM.0000240233.01711.D9.

Reference Type RESULT
PMID: 16932234 (View on PubMed)

Other Identifiers

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Predictors of vap mortality

Identifier Type: -

Identifier Source: org_study_id

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