Aerobic Capacity Muscle Strength and Health Related Quality of Life in Children With Chronic Liver Disease

NCT ID: NCT06240832

Last Updated: 2024-02-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 18 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-06-22
• Study Completion Date: 2023-06-22

Brief Summary

Physical therapy program for children with chronic liver disease consist of gait training, strengthening ex for UL&ll, stretching exercise to improve physical fitness and quality of life

Detailed Description

Intervention study for one group of children diagnosed with chronic liver disease ages more than 6ys, study include assessment and intervention, assessment of 6MWt, grip strength by hand held dynamometer, quadriceps strength by Lafayette, al children subjected to laboratory investigation pre and post of study completion, anthropometric measure, quality of life and fatigue assessment then all children will perform physical therapy program of gait training muscle strengthening for 8 week

Conditions

Chronic Liver Failure

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Aerobic and strength training in children with CLD

AEROBIC AND STRENGTHENING EXERCISE USING TREADMILL AND WEIGHT TO IMPROVE FUNCTIONAL OUTCOMES IN CHILDREN WITH CHRONIC LIVER DISEASE

Group Type: EXPERIMENTAL

Physical therapy exercise

Intervention Type: OTHER

Endurance, strength and stretching training in Chronic liver disease children

Interventions

Physical therapy exercise

Endurance, strength and stretching training in Chronic liver disease children

Intervention Type: OTHER

Other Intervention Names

Designated physical therapy program

Eligibility Criteria

Inclusion Criteria

• Their age ranged from7 to14 years old.
• Residence in Cairo to be able to attend the rehabilitation program.
• Diagnosis of CLD as (Wilson disease, autoimmune hepatitis, chronic cholestasis , ….etc).
• All children were medically stabled
• All children had the same socioeconomic status

Exclusion Criteria

• Complication that prevent children from performing maximal exercise test as fracture of both upper and lower limbs, cardiovascular instability and muscle disease in patient with glycogen storage disease(GSD) or abnormal creatine phosphokinase(CPK).
• Patients with cognitive and motor disorders as in case of hepatic encephalopathy and or ascites.
• Patients who underwent liver transplantation.
• Patient with end stage liver disease.
• History of variceal bleeding from one month ago or less.
• No other system disease (chest, cardiac and nervous system).
• Medical examination no hernia.

• Minimum Eligible Age: 7 Years
• Maximum Eligible Age: 14 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Heba Ibrahim

assistant lecturer, pediatric department of physical therapy,principle investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Heba A IBRAHIM

Role: PRINCIPAL_INVESTIGATOR

Cairo University

Locations

Cairo university

Cairo, , Egypt

Countries

Egypt

References

Zenith L, Meena N, Ramadi A, Yavari M, Harvey A, Carbonneau M, Ma M, Abraldes JG, Paterson I, Haykowsky MJ, Tandon P. Eight weeks of exercise training increases aerobic capacity and muscle mass and reduces fatigue in patients with cirrhosis. Clin Gastroenterol Hepatol. 2014 Nov;12(11):1920-6.e2. doi: 10.1016/j.cgh.2014.04.016. Epub 2014 Apr 24.

Reference Type: RESULT

PMID: 24768811 (View on PubMed)

Other Identifiers

P. T. REC/012/003479

Identifier Type: -

Identifier Source: org_study_id