Management of Neuromuscular Blocking Agents and Their Antagonism

NCT ID: NCT06238219

Last Updated: 2024-04-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

3000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-04-17

Study Completion Date

2024-12-31

Brief Summary

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Neuromuscular blocking agents (NMBA) are commonly used in clinical practice during general anesthesia to facilitate induction, intubation and surgery. Some studies have shown that their use can be deleterious if not codified. Recent recommendations concerning their use and antagonization were published in 2023.

Research hypothesis:

Using a single-center, retrospective practice study, we aim to analyze whether the 2023 ASA and ESAIC recommendations are being implemented regarding the use of neuromuscular blocking agents.

Detailed Description

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Conditions

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Neuromuscular Blocking Agents Neuromuscular Monitoring

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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NMBA cohort

Patients undergoing surgery under general anesthesia with use of neuromuscular blocking agents

Neuromuscular Blocking Agent

Intervention Type DRUG

Administration of any neuromuscular blocking agent for surgery under general anesthesia

Interventions

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Neuromuscular Blocking Agent

Administration of any neuromuscular blocking agent for surgery under general anesthesia

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

\- All patients undergoing surgery with use of neuromuscular blocking agents at our institution

Exclusion Criteria

\- Incomplete electronic anesthesia record
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Erasme University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hôpital Universitaire de Bruxelles - Hôpital erasme

Brussels, , Belgium

Site Status RECRUITING

Countries

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Belgium

Central Contacts

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Denis Schmartz, MD

Role: CONTACT

+3225553919

Andréa Gardon, MD

Role: CONTACT

+3225553919

Facility Contacts

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Denis Schmartz, MD

Role: primary

+3225553919

References

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Kirmeier E, Eriksson LI, Lewald H, Jonsson Fagerlund M, Hoeft A, Hollmann M, Meistelman C, Hunter JM, Ulm K, Blobner M; POPULAR Contributors. Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study. Lancet Respir Med. 2019 Feb;7(2):129-140. doi: 10.1016/S2213-2600(18)30294-7. Epub 2018 Sep 14.

Reference Type BACKGROUND
PMID: 30224322 (View on PubMed)

Blobner M, Hunter JM, Meistelman C, Hoeft A, Hollmann MW, Kirmeier E, Lewald H, Ulm K. Use of a train-of-four ratio of 0.95 versus 0.9 for tracheal extubation: an exploratory analysis of POPULAR data. Br J Anaesth. 2020 Jan;124(1):63-72. doi: 10.1016/j.bja.2019.08.023. Epub 2019 Oct 10.

Reference Type BACKGROUND
PMID: 31607388 (View on PubMed)

Fuchs-Buder T, Brull SJ. Is less really more? A critical appraisal of a POPULAR study reanalysis. Br J Anaesth. 2020 Jan;124(1):12-14. doi: 10.1016/j.bja.2019.09.038. Epub 2019 Nov 2. No abstract available.

Reference Type BACKGROUND
PMID: 31685216 (View on PubMed)

Thilen SR, Weigel WA, Todd MM, Dutton RP, Lien CA, Grant SA, Szokol JW, Eriksson LI, Yaster M, Grant MD, Agarkar M, Marbella AM, Blanck JF, Domino KB. 2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade. Anesthesiology. 2023 Jan 1;138(1):13-41. doi: 10.1097/ALN.0000000000004379.

Reference Type BACKGROUND
PMID: 36520073 (View on PubMed)

Fuchs-Buder T, Romero CS, Lewald H, Lamperti M, Afshari A, Hristovska AM, Schmartz D, Hinkelbein J, Longrois D, Popp M, de Boer HD, Sorbello M, Jankovic R, Kranke P. Peri-operative management of neuromuscular blockade: A guideline from the European Society of Anaesthesiology and Intensive Care. Eur J Anaesthesiol. 2023 Feb 1;40(2):82-94. doi: 10.1097/EJA.0000000000001769. Epub 2022 Nov 15.

Reference Type BACKGROUND
PMID: 36377554 (View on PubMed)

Other Identifiers

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SRB2024007

Identifier Type: -

Identifier Source: org_study_id

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