Efficacy and Safety of DIT112 in the Treatment of Moderate to Severe Pain After Dental Surgery for the Extraction of Impacted Third Molars

NCT ID: NCT06237231

Last Updated: 2024-02-20

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 252 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-02-15
• Study Completion Date: 2027-04-10

Brief Summary

The purpose of this study is to evaluate the efficacy and safety of DIT112 in adolescents and adults with acute pain after dental surgery for the extraction of impacted third molars.

Conditions

Moderate Pain; Severe Pain

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

DIT112

The study is triple-dummy. The patient must take 3 pills, with a minimum interval of 6/6 hours for 3 days, if pain, as follows:

1 tablet DIT112, oral;

1 capsule tramadol placebo, oral;

1 tablet dipyrone placebo, oral.

Group Type: EXPERIMENTAL

DIT112

Intervention Type: DRUG

DIT112 tablet

Dipyrone Placebo

Intervention Type: DRUG

Dipyrone placebo tablet

Tramadol Placebo

Intervention Type: DRUG

Tramadol placebo capsule

DIPYRONE

The patient must take 3 pills, with a minimum interval of 6/6 hours for 3 days, if pain, as follows:

1 tablet dipyrone, oral;

1 tablet DIT112 placebo, oral;

1 capsule tramadol placebo, oral.

Group Type: ACTIVE_COMPARATOR

DIPYRONE

Intervention Type: DRUG

Dipyrone tablet 1.000mg

DIT112 Placebo

Intervention Type: DRUG

DIT112 placebo tablet

Tramadol Placebo

Intervention Type: DRUG

Tramadol placebo capsule

TRAMADOL

The patient must take 3 pills, with a minimum interval of 6/6 hours for 3 days, if pain, as follows:

1 capsule tramadol, oral;

1 tablet dipyrone placebo, oral;

1 tablet DIT112 placebo, oral.

Group Type: ACTIVE_COMPARATOR

TRAMADOL

Intervention Type: DRUG

Tramadol tablet 50mg

DIT112 Placebo

Intervention Type: DRUG

DIT112 placebo tablet

Dipyrone Placebo

Intervention Type: DRUG

Dipyrone placebo tablet

Interventions

DIT112

DIT112 tablet

Intervention Type: DRUG

DIPYRONE

Dipyrone tablet 1.000mg

Intervention Type: DRUG

TRAMADOL

Tramadol tablet 50mg

Intervention Type: DRUG

DIT112 Placebo

DIT112 placebo tablet

Intervention Type: DRUG

Dipyrone Placebo

Dipyrone placebo tablet

Intervention Type: DRUG

Tramadol Placebo

Tramadol placebo capsule

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Ability to confirm voluntary participation and agree with all the purposes of the trial, signing and dating the Free and Informed Consent Form (TCLE) and/or the Free and Informed Assent Form (TALE) in two copies;
• Age equal to or over 15 years old;
• Indication of extraction of two (02) impacted third molars, one (01) lower third molar and one (01) upper molar on the same side;
• Third molar with bone impactions observed through panoramic radiography, with classification by Winter (1926) (1) mesioangular or vertical, and classification according to Pell & Gregory (1933) (2):

i. Class II position B; or ii. Class III position A or B

• Presence of pain of moderate or severe intensity (score greater than or equal to 5 when assessed using an 11-point numeric pain scale) within up to four (04) hours after the end of the surgery.

Exclusion Criteria

• Presence of local conditions (lesions in the region of the third molars) that may interfere with the extraction of third molars, such as, but not limited to, pericoronitis, periodontitis, tumors, cysts and inflammation and/or infection in the region to be operated;
• Presence of any clinical observation finding (clinical/physical assessment) or laboratory condition that is interpreted by the investigating physician as a risk to the research participant's participation in the clinical trial or the presence of uncontrolled chronic disease(s);
• Presence of a known gastroduodenal ulcer or diagnosis of persistent gastritis;
• Presence of compromised bone marrow function or diseases of the hematopoietic system;
• Presence of known severe renal and/or hepatic insufficiency;
• Diagnosis of epilepsy not adequately controlled;
• Diagnosis of acute intermittent hepatic porphyria;
• Presence of known congenital glucose-6-phosphatedehydrogenase deficiency;
• History of allergy or intolerance to tramadol, diclofenac and pyrazolones (e.g. phenazone, propyphenazone) or pyrazolidines (e.g. phenylbutazone, oxyphenbutazone) including, for example, previous experience of agranulocytosis with one of these substances;
• Use of sedative, hypnotic or psychotropic medications in the last 24 hours before surgery;
• Use of anticoagulant medications in the last seven (07) days before surgery;
• Current chronic treatment with opioids or corticosteroids;
• Current treatment with selective cyclooxygenase - 2 (COX2) inhibitors;
• Use of monoamine oxidase inhibitors (MAOIs) such as, but not limited to, phenelzine, tranylcypromine and isocarboxazid, in the last 14 days prior to the day of surgery;
• Use of any analgesic and/or anti-inflammatory medication in the three (03) days prior to the day of surgery;
• Known allergy or hypersensitivity to the components of the medicines used during the clinical trial;
• Surgery to extract third molars lasting more than 60 minutes, considering from the beginning of the incision until the end of the extraction;
• Technical failure in anesthesia or need to administer more than three tubes of anesthetic for each molar;
• Presence of temporomandibular joint dysfunction or limited mouth opening;
• Occurrence of a surgical accident resulting from the extraction of impacted third molars which, in the opinion of the investigator, could interfere with the procedures or evaluations of the trial, such as, but not limited to, intraoperative hemorrhage, probable injury to the inferior alveolar nerve, board fracture bone and soft tissue laceration;
• Current medical history of cancer and/or cancer treatment in the last 5 years;
• History of alcohol and/or illicit drug abuse disorder in the last two (02) years;
• Participants who are pregnant, breastfeeding or planning to become pregnant, or female participants of childbearing potential who are not using a reliable method of contraception;
• Participation in clinical trial protocols in the last 12 (twelve) months (CNS Resolution 251, of August 7, 1997, item III, subitem J), unless the investigator believes that there may be a direct benefit to the participant.

• Minimum Eligible Age: 15 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

EMS

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Other Identifiers

DIT112-III-0123

Identifier Type: -

Identifier Source: org_study_id