Study of Long-Acting Acetaminophen in Postoperative Dental Pain

NCT ID: NCT01960114

Last Updated: 2015-07-10

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

403 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-10-31

Study Completion Date

2014-04-30

Brief Summary

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The purpose of the study is to evaluate the efficacy and safety of acetaminophen ER 1500 mg (two 750 mg tablets) over 10 to 12 hours in the dental pain model following third molar extraction(s) and to evaluate the pharmacokinetics of acetaminophen ER 1500 mg (two 750 mg tablets) in a sub-group of subjects.

Detailed Description

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Conditions

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Dental Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Acetaminophen ER

Group Type EXPERIMENTAL

Acetaminophen ER

Intervention Type DRUG

Single dose (2 tablets) Acetaminophen ER 750 mg

Placebo

Single dose (2 tablets) Acetaminophen ER 750 mg matching placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Single dose (2 tablets) Acetaminophen ER 750 mg matching placebo

Interventions

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Acetaminophen ER

Single dose (2 tablets) Acetaminophen ER 750 mg

Intervention Type DRUG

Placebo

Single dose (2 tablets) Acetaminophen ER 750 mg matching placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Must be at least 17 and less than 46 years of age
* Must weigh at least 100 lbs with a body mass index of at least 18 and less than 30
* Scheduled to undergo surgical extraction of one impacted third molar from the lower jaw. The third molar from the upper jaw from the same side may also be removed.
* Experiencing moderate to severe pain after extraction of third molars.

Exclusion Criteria

* Cannot be allergic to acetaminophen (Tylenol) or any non-steroidal anti-inflammatory drugs (e.g., Motrin, Advil, Aleve, Naproxen).
* Cannot be pregnant (or planning to be pregnant) or nursing a baby
* Unable to swallow whole large tablets or caplets.
* Cannot have any other medical conditions that the investigator feels may compromise your safety or the study results.
Minimum Eligible Age

17 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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McNeil Study Director

Role: STUDY_DIRECTOR

McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.

Locations

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Jean Brown Research

Salt Lake City, Utah, United States

Site Status

Countries

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United States

Other Identifiers

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AERPAI2001

Identifier Type: -

Identifier Source: org_study_id

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