Phase 3 Study of Tramadol Hydrochloride/Acetaminophen SR Tab. & Tramadol Hydrochloride/Acetaminophen Tab. in Acute Toothache Patients After Teeth Extraction Surgery

NCT ID: NCT01920386

Last Updated: 2016-10-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

240 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-06-30

Brief Summary

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A randomized, double-blind, active-controlled, parallel, multicenter Phase 3 study of Tramadol hydrochloride/Acetaminophen SR Tab. \& Tramadol hydrochloride/Acetaminophen Tab. in Acute Toothache Patients above Moderate Pain after Teeth Extraction Surgery.

Detailed Description

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Conditions

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Acute Toothache Patients Above Moderate Pain After Teeth Extraction Surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Tramadol hydrochloride/Acetaminophen Tab.

1tab PO within 5hours from teeth extraction

Group Type ACTIVE_COMPARATOR

Tramadol hydrochloride/Acetaminophen Tab.

Intervention Type DRUG

Tramadol hydrochloride/Acetaminophen SR Tab.

1tab PO within 5hours from teeth extraction and then 1tab more after 6hours

Group Type EXPERIMENTAL

Tramadol hydrochloride/Acetaminophen SR Tab.

Intervention Type DRUG

Interventions

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Tramadol hydrochloride/Acetaminophen Tab.

Intervention Type DRUG

Tramadol hydrochloride/Acetaminophen SR Tab.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Adult males/Females aged over 20 years
2. Patients with over 2 impacted wisdom teeth in the upper and lower jaws
3. Pain VAS Value over 50 mm evaluated as 100mm VAS
4. Subjects who voluntarily or legal guardian agreed with written consent

Exclusion Criteria

1. Patients with severe heart disease, uncontrol hypertension, diabetes
2. Patients who had taken a long period NSAID (eg. celecoxib, rofecoxib naproxen etc) within 3 days from the screening point
3. Patients who had taken short-time anesthetic drugs and analgesics within 12 hours from the screening point (except short-time anesthetics before or during surgery)
4. Patients with aspirin asthma(asthma seizure caused by NSAIDs) or medical history
5. Patients with severe respiratory depression
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Daewon Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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DW 0919 302 Version 1.0

Identifier Type: -

Identifier Source: org_study_id

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