CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study
NCT ID: NCT06220396
Last Updated: 2025-11-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
80 participants
INTERVENTIONAL
2026-01-31
2029-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Healthy Volunteers
Healthy volunteers with no history of Heart Failure (HF) will undergo a Right Heart Catheterization with Hemodynamics and Limited Echocardiogram, MRI, and DEXA scan.
Right Heart Catheterization with Hemodynamics and Limited Echocardiogram
Right Heart Catheterization (RHC) with Hemodynamics and Limited Echocardiogram is an invasive procedure that involves insertion of a catheter through a blood vessel in the neck, groin, or arm to the right side of the heart. Hemodynamic measurements such as the blood pressure inside the veins, heart, and arteries as well as measurements of blood flow and how much oxygen is in the blood will be completed during the catheterization procedure. It is a way to see how well the heart is working during your procedure. During the RHC procedure a limited echocardiogram, using ultrasound waves, will be collected to evaluate the structure and function of the heart.
All measurements will be conducted at rest and during exercise using a supine cycle ergometer
Magnetic Resonance Imaging (MRI)
MRI is a medical imaging technique that uses a magnetic field and computer-generated radio waves to create detailed images of the organs and tissues in your body. CMR Imaging will assess myocardial structure, function, and fat content.
An additional limited MRI sequence of the the abdomen and one sequence in the thigh will be used to evaluate for visceral adipose tissue (VAT) as a measurement of body composition.
Dual X-ray absorptiometry (DEXA) scan
A DEXA scan measures the amount of fat in the body using an x-ray that measures bone, calcium and fat.
Interventions
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Right Heart Catheterization with Hemodynamics and Limited Echocardiogram
Right Heart Catheterization (RHC) with Hemodynamics and Limited Echocardiogram is an invasive procedure that involves insertion of a catheter through a blood vessel in the neck, groin, or arm to the right side of the heart. Hemodynamic measurements such as the blood pressure inside the veins, heart, and arteries as well as measurements of blood flow and how much oxygen is in the blood will be completed during the catheterization procedure. It is a way to see how well the heart is working during your procedure. During the RHC procedure a limited echocardiogram, using ultrasound waves, will be collected to evaluate the structure and function of the heart.
All measurements will be conducted at rest and during exercise using a supine cycle ergometer
Magnetic Resonance Imaging (MRI)
MRI is a medical imaging technique that uses a magnetic field and computer-generated radio waves to create detailed images of the organs and tissues in your body. CMR Imaging will assess myocardial structure, function, and fat content.
An additional limited MRI sequence of the the abdomen and one sequence in the thigh will be used to evaluate for visceral adipose tissue (VAT) as a measurement of body composition.
Dual X-ray absorptiometry (DEXA) scan
A DEXA scan measures the amount of fat in the body using an x-ray that measures bone, calcium and fat.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Patients will also be required to have left ventricular ejection fraction (EF) ≥ 50%.
* Patients discovered to reduced EF or abnormal resting hemodynamics or other pathologic findings previously undiscovered will be considered screen failures and can be replaced by others to reach the goal enrollment.
* Informed consent were obtained.
* No history of heart failure.
* Willing and able to undergo invasive hemodynamic exercise testing, MRI, and other study assessments.
Exclusion Criteria
* Any diagnosis of heart failure
* Symptomatic coronary artery disease (e.g., patients with chronic angina)
* Symptomatic valvular heart disease
* Pulmonary hypertension
* Cardiomyopathies
* High output heart failure
* Pericardial disease
* Clinically significant chronic lung disease in the opinion of the investigators
* Anemia (hemoglobin \<12 gm/dL in women and \<13 gm/dL in men)
* Estimated glomerular filtration rate ≤30mL/min
* Pregnant women
* Any other disorders or problems that would interfere with the ability to participate safely in the study (e.g. psychiatric disorder or substance abuse)
30 Years
ALL
Yes
Sponsors
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Mayo Clinic
OTHER
Responsible Party
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Barry Borlaug
Principal Investigator
Principal Investigators
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Barry Borlaug, MD
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, United States
Countries
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Central Contacts
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Facility Contacts
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Dr. Borlaug's Research Team
Role: primary
Other Identifiers
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23-007522
Identifier Type: -
Identifier Source: org_study_id
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