Effects of Exercise Mode on Cardiac Fat and Function

NCT ID: NCT03297333

Last Updated: 2021-10-04

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 18 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-10-01
• Study Completion Date: 2020-03-16

Brief Summary

The overall goal of this project is to study the effects of exercise energy expenditure matched vigorous dynamic resistance training and aerobic training on cardiac fat, and its relationship to cardiac function and geometry using cardiac Magnetic Resonance Imaging.

Detailed Description

Exercise-induced weight-loss is one of the most common strategies for reducing excess fat in overweight and obese individuals. Although vigorous intensity may be more favorable promoting positive cardiac adaptations compared to low-moderate intensity, evidence of the positive effects of different exercise modes needs to be explored to allow for realistic comparisons with other strategies. Research using cardiac Magnetic Resonance Imaging that compares the effects of different modes of exercise - matched by exercise energy expenditure - on epicardial adipose tissue and paracardial adipose tissue, and how these interventions modify cardiac function and geometry have not been previously explored in obesity.

Conditions

Obesity

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Resistance training group

Resistance training will consist of a supervised circuit training 3 sessions/week for approximately 45-50 min/session. The circuit will include 7 strength exercises engaging the major muscle groups (leg press, rows, back squats, weighted crunches, deadlifts, bench press, and squat jumps with weights). The participants will perform 3 sets of 10 repetitions with resting periods of 30 seconds between exercises, and 2 minutes between sets. The overall OMNI-Resistance Exercise Scale per set will range between 8-10. Heart rate and exercise energy expenditure during the workout will be monitored. The load will be changed depending on the participants' perception when needed. In addition, the intensity will be monitored assessing Lactate concentrations at baseline and at the end of each session. Circuit will be repeated until meeting the targeted exercise energy expenditure of 450-500 kcal/session.

Group Type: EXPERIMENTAL

Resistance training

Intervention Type: OTHER

The resistance training group

Aerobic interval training group

Aerobic interval will consist of a supervised aerobic interval training sessions 3 times/week. Duration will range between 45-50 min/session depending on the exercise energy expenditure. Each interval will have a total duration of 5 min, and it will be divided into 2 periods. The first period will consist of 3 minutes of high-intensity activity, and the second period the intensity will be reduced for 2 minutes. The speed/incline will be changed depending on the participants' heart rate and perception using the Borg's rating of perceived exertion as needed. Heart rate and exercise energy expenditure during the workout will be monitored. Intensity will be monitored assessing Lactate concentrations at the end of each session. Intervals will be repeated until meeting the targeted exercise energy expenditure (450-500 kcal/session).

Group Type: EXPERIMENTAL

Aerobic interval training

Intervention Type: OTHER

The aerobic interval training group

Control group

Participants in the control group will not participate in the training programs.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Resistance training

The resistance training group

Intervention Type: OTHER

Aerobic interval training

The aerobic interval training group

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Sedentary
• Caucasian
• BMI >30 kg/m2 and < 39.9 kg/m2

Exclusion Criteria

• Known cardiovascular, metabolic, pulmonary disease or conditions
• Muscular-skeletal injuries
• Taking medications that affect endocrine or cardiovascular function
• Hypertension
• Being engaged in low intensity strength training more than two times per week or moderate-high intensity of any type of frequency
• Being pregnant
• Cigarette smoking
• Having non-removable pieces or devices incompatible with DXA and CMR assessment.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Southern Illinois University Edwardsville

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Maria Fernandez del Valle, PhD

Role: PRINCIPAL_INVESTIGATOR

Southern Illinois University of Edwardsville

Locations

Southern Illinois University of Edwardsville

Edwardsville, Illinois, United States

Countries

United States

Other Identifiers

16-1208-4C-1

Identifier Type: -

Identifier Source: org_study_id