IDH1 and OCT4 in High Grade Astrocytoma

NCT ID: NCT06214689

Last Updated: 2024-08-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

35 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-09-30

Study Completion Date

2025-08-31

Brief Summary

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observation of IDH1 and OCT4 markers level and high grade astrocytoma patients prognosis after excision.

Detailed Description

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explore the relationship between prognosis and IDH1 and OCT4 biomarkers after high grade astrocytoma excision , according to progression free survival and overall survival , in prospective and retrospective samples.

Conditions

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High Grade Astrocytoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Interventions

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biomarkers analysis

IDH1 and OCT4 markers analysis of surgical specimens of high grade astrocytoma

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients of high grade astrocytic glioma patients fit for surgery

Exclusion Criteria

* patients of low grade glioma patients unfit for surgery
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Abdelrahman Ata Salama Swefy

doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Faculty of Medicine of Assiut University

Asyut, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Abdelrahman A Salama, resident

Role: CONTACT

01002796190

Mahmoud H Ragab, professor

Role: CONTACT

01004001789

Facility Contacts

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Abdelrahman A Salama, resident

Role: primary

01002796190

Mahmoud H Ragab, professor

Role: backup

01004001789

References

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PubMed

Reference Type BACKGROUND

Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS. The epidemiology of glioma in adults: a "state of the science" review. Neuro Oncol. 2014 Jul;16(7):896-913. doi: 10.1093/neuonc/nou087.

Reference Type RESULT
PMID: 24842956 (View on PubMed)

Perry A, Wesseling P. Histologic classification of gliomas. Handb Clin Neurol. 2016;134:71-95. doi: 10.1016/B978-0-12-802997-8.00005-0.

Reference Type RESULT
PMID: 26948349 (View on PubMed)

Sathornsumetee S, Rich JN, Reardon DA. Diagnosis and treatment of high-grade astrocytoma. Neurol Clin. 2007 Nov;25(4):1111-39, x. doi: 10.1016/j.ncl.2007.07.004.

Reference Type RESULT
PMID: 17964028 (View on PubMed)

Other Identifiers

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biomarkers in astrocytoma

Identifier Type: -

Identifier Source: org_study_id

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