Effects of Movement Retraining on Knee Loading in Individuals With Knee Osteoarthritis
NCT ID: NCT06208631
Last Updated: 2025-10-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
31 participants
INTERVENTIONAL
2024-01-18
2026-12-31
Brief Summary
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Prior research has utilized musculoskeletal simulations to determine that reducing the activation of one of the calf muscles, the gastrocnemius, can have a large impact on reducing knee loading. However, this has not been tested in individuals with knee osteoarthritis. In this study, participants will be trained to alter the activation of their gastrocnemius muscle, by receiving haptic feedback after each step. The feedback will indicate how the participant changed their muscle activation relative to baseline. Some participants will train on a treadmill in the laboratory for up to two sessions, with 30 minutes of walking with feedback in each session. If a participant can learn to adjust their muscle activation in the first training session, they will be able to complete the second training session. Other participants will train outside the laboratory for one session with 30 minutes of walking with feedback to investigate changes in knee loading while using the new walking strategy during over-ground walking.
The movement data collected during the training sessions will be used as inputs to computer simulations of the musculoskeletal system to determine if walking with the new muscle activation strategy reduces knee loading.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
OTHER
NONE
Study Groups
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Gait modification
Participants will learn to change muscle coordination while walking through real-time haptic biofeedback based on the activation of the gastrocnemius muscle
Gait retraining
Changing muscle coordination while walking
Interventions
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Gait retraining
Changing muscle coordination while walking
Eligibility Criteria
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Inclusion Criteria
* Diagnosed with knee osteoarthritis of at least six months duration
* Ambulatory without aids
* Able to walk for at least 60 minutes
* Typical pain rating less than or equal to 4 on scale of 0-10
* Able to reduce gastrocnemius muscle activation by 10% from baseline
Exclusion Criteria
* Replacement of any lower extremity joint
* Symptoms originating from the patellofemoral joint
* Body mass index equal to or greater than 35
* Nerve or muscle disease associated with walking difficulty
* History of rheumatoid arthritis, gout, or autoimmune disease
* History of lower limb fracture or surgery requiring hospitalization
* Pregnant
18 Years
ALL
No
Sponsors
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Stanford University
OTHER
Responsible Party
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Scott Delp
Professor of Bioengineering and Mechanical Engineering
Principal Investigators
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Scott L Delp, PhD
Role: PRINCIPAL_INVESTIGATOR
Stanford University
Locations
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Stanford Human Performance Lab
Stanford, California, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Lee KJ, Hahm KB, Kim YS, Kim JH, Cho SW, Jie H, Park CH, Yim H. The usefulness of Tc-99m HMPAO labeled WBC SPECT in eosinophilic gastroenteritis. Clin Nucl Med. 1997 Aug;22(8):536-41. doi: 10.1097/00003072-199708000-00005.
Kather L, Smidt D. [Composition of porcine uterine secretion]. Berl Munch Tierarztl Wochenschr. 1974 Oct 1;87(19):372-4. No abstract available. German.
Other Identifiers
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34928
Identifier Type: -
Identifier Source: org_study_id
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